2. Gene
  3. TSC22D1 - TSC22 domain family member 1 Gene

TSC22D1 - TSC22 domain family member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Ptg-2; TSC22; TGFB1I4

Gene ID: 8848 | Gene type: protein coding

About TSC22D1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:44,432,143-44,577,344 (from NCBI)

This gene has 13 transcripts (splice variants), 212 orthologues and 3 paralogues. Ubiquitous expression in prostate (RPKM 33.1), endometrium (RPKM 31.6) and 25 other tissues.

Summary

This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of Cancer cell Apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

TSC22D1 Products(5)

mRNA Protein Name
NM_001243797.2 NP_001230726.1 TSC22 domain family protein 1 isoform 3
NM_001243798.2 NP_001230727.1 TSC22 domain family protein 1 isoform 3
NM_001243799.1 NP_001230728.1 TSC22 domain family protein 1 isoform 4
NM_006022.4 NP_006013.1 TSC22 domain family protein 1 isoform 2
NM_183422.4 NP_904358.2 TSC22 domain family protein 1 isoform 1

TSC22D1 Protein Structure

TSC22

TSC22: TSC-22/dip/bun family (988 - 1045)

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  • 1073 a.a.
Protein Preferred Names Protein Names

TSC22 domain family protein 1

TGFB-stimulated clone 22 homolog

Recombinant TSC22D1 Proteins

Cat. No. Product Name Accession Purity
HY-P76685 TSC22/TSC22D1 Protein, Human (His) Q15714-2 (M1-A144) ≥95%

Related Diseases

Diseases Alias
Brain Sarcoma

Sarcoma Of The Brain
Salivary Gland Carcinoma

Salivary Gland Cancer

Malignant Neoplasm Of Salivary Gland

Salivary Gland Neoplasms
Cogan-Reese Syndrome
Testicular Malignant Germ Cell Cancer

Malignant Germ Cell Tumor Of Testis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15133 TSC22D1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TSC22D1 VGNC VGNC:47892
Mus musculus TSC22D1 MGD MGI:109127
Macaca mulatta TSC22D1 VGNC VGNC:79053
Felis catus TSC22D1 VGNC VGNC:66607
Rattus norvegicus TSC22D1 RGD RGD:3850
Others TSC22D1 NCBI