TSC22D1 - TSC22 domain family member 1 Gene

Homo sapiens

Also known as Ptg-2; TSC22; TGFB1I4

Gene ID: 8848 | Gene type: protein coding

About TSC22D1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:44,432,143-44,577,344 (from NCBI)

This gene has 13 transcripts (splice variants), 212 orthologues and 3 paralogues. Ubiquitous expression in prostate (RPKM 33.1), endometrium (RPKM 31.6) and 25 other tissues.

Summary

This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of Cancer cell Apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

TSC22D1 Products(5)

mRNA	Protein	Name
NM_001243797.2	NP_001230726.1	TSC22 domain family protein 1 isoform 3
NM_001243798.2	NP_001230727.1	TSC22 domain family protein 1 isoform 3
NM_001243799.1	NP_001230728.1	TSC22 domain family protein 1 isoform 4
NM_006022.4	NP_006013.1	TSC22 domain family protein 1 isoform 2
NM_183422.4	NP_904358.2	TSC22 domain family protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	26752201	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15881652	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	15881652	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18325344	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21791611	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21791611	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	34681573	GOA
located in nucleus	IDA IDA: Inferred from direct assay	34681573	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21791611	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSC22D1 Protein Structure

TSC22

0
200
400
600
800
1000
1073 a.a.

Protein Preferred Names

Protein Names

TSC22 domain family protein 1

TGFB-stimulated clone 22 homolog

TSC22D1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSC22D1	Q15714	TPT1	Homo sapiens	P13693	Pull Down	18325344
Intra	TSC22D1	Q15714	TPT1	Homo sapiens	P13693	Anti Bait CoIP	18325344
Intra	TSC22D1	Q15714	TPT1	Homo sapiens	P13693	Y2H	18325344
Intra	TSC22D1	Q15714	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	TSC22D1	Q15714	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	TSC22D1	Q15714	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TSC22D1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76685	TSC22/TSC22D1 Protein, Human (His)	Q15714-2 (M1-A144)	≥95%

Related Diseases

Diseases

Alias

Brain Sarcoma

Sarcoma Of The Brain

Salivary Gland Carcinoma

Salivary Gland Cancer	Malignant Neoplasm Of Salivary Gland
Salivary Gland Neoplasms

Cogan-Reese Syndrome

Testicular Malignant Germ Cell Cancer

Malignant Germ Cell Tumor Of Testis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15133	TSC22D1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TSC22D1	VGNC	VGNC:47892
Mus musculus	TSC22D1	MGD	MGI:109127
Macaca mulatta	TSC22D1	VGNC	VGNC:79053
Felis catus	TSC22D1	VGNC	VGNC:66607
Rattus norvegicus	TSC22D1	RGD	RGD:3850
Others	TSC22D1	NCBI

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