VNN2 - vanin 2 Gene

Homo sapiens

Also known as FOAP-4; GPI-80

Gene ID: 8875 | Gene type: protein coding

About VNN2

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,743,870-132,763,455 (from NCBI)

This gene has 16 transcripts (splice variants), 127 orthologues and 2 paralogues. Biased expression in spleen (RPKM 12.9), lymph node (RPKM 11.0) and 11 other tissues.

Summary

This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each Other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two Other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

VNN2 Products(3)

mRNA	Protein	Name
NM_001242350.3	NP_001229279.2	pantetheine hydrolase VNN2 isoform 3 precursor
NM_004665.6	NP_004656.3	pantetheine hydrolase VNN2 isoform 1 precursor
NM_078488.3	NP_511043.2	pantetheine hydrolase VNN2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables pantetheine hydrolase activity	IDA IDA: Inferred from direct assay	11491533	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in pantothenate metabolic process	IDA IDA: Inferred from direct assay	11491533	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VNN2 Protein Structure

CN_hydrolase

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

pantetheine hydrolase VNN2

Vannin 2

VNN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VNN2	O95498	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	VNN2	O95498	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	VNN2	O95498	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	VNN2	O95498	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	VNN2	O95498	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	VNN2	O95498	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VNN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71045	VNN2/Vanin-2 Protein, Human (HEK293, His)	O95498 (Q23-S492)	≥95%

Related Diseases

Diseases

Alias

Trichuriasis

Whipworm Infection	Whipworm Disease
Trichocephaliasis	Infection By Trichuris Trichura
Trichuriasis Infection	Trichuris Trichiura Infection
Infection By Trichuris Trichiura	Trichocephalosis
Infection By Trichocephalus Trichiura	Infection By Trichuris
Infection By Trichuris Trichiuria	Trichuriosis
Whipworm	Infection Due To Trichuris Trichiura
Trichocephalus Infestation	Trichuris Infestation
Whipworm Infestation

Localized Chondrosarcoma

Biotin Deficiency

Biotin Deficiency Disease	B7 Deficiency
Biotan Vitamin Deficiency

Cystinosis

Cystine Storage Disease	Cystine Diathesis
Cystine Disease	Cystinoses
Protein Defect Of Cystin Transport	Cystin Transport, Protein Defect Of
Nephropathic Cystinosis	Protein Defect Of Cystine Transport

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15667	VNN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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