BUD31 - BUD31 homolog Gene

Homo sapiens

Also known as G10; EDG2; Cwc14; EDG-2; fSAP17; YCR063W

Gene ID: 8896 | Gene type: protein coding

About BUD31

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,408,969-99,419,616 (from NCBI)

This gene has 9 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in testis (RPKM 25.3), bone marrow (RPKM 23.9) and 25 other tissues.

Summary

Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Involved in mRNA splicing, via spliceosome and positive regulation of Androgen Receptor activity. Located in nucleus. Part of U2-type catalytic step 2 spliceosome. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]

BUD31 Products(3)

mRNA	Protein	Name
NM_001370407.1	NP_001357336.1	protein BUD31 homolog
NM_001370410.1	NP_001357339.1	protein BUD31 homolog
NM_003910.4	NP_003901.2	protein BUD31 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear receptor binding	IDA IDA: Inferred from direct assay	25091737	GOA
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	25091737	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25091737	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
involved in positive regulation of androgen receptor activity	IDA IDA: Inferred from direct assay	25091737	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
located in chromatin	IDA IDA: Inferred from direct assay	25091737	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BUD31 Protein Structure

G10

0
100
144 a.a.

Protein Preferred Names

Protein Names

protein BUD31 homolog

G10 maternal transcript homolog

BUD31 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BUD31	P41223	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	BUD31	P41223	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
Intra	BUD31	P41223	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	BUD31	P41223	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	BUD31	P41223	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	BUD31	P41223	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	BUD31	P41223	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	BUD31	P41223	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	BUD31	P41223	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	BUD31	P41223	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	BUD31	P41223	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	BUD31	P41223	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	BUD31	P41223	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01686	BUD31 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BUD31	VGNC	VGNC:26609
Macaca mulatta	BUD31	VGNC	VGNC:70441
Mus musculus	BUD31	MGD	MGI:2141291
Rattus norvegicus	BUD31	RGD	RGD:621103
Felis catus	BUD31	VGNC	VGNC:60213

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