PRPF4B - pre-mRNA processing factor 4B Gene

Homo sapiens

Also known as PR4H; PRP4; PRP4H; PRP4K; dJ1013A10.1

Gene ID: 8899 | Gene type: protein coding

About PRPF4B

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:4,021,300-4,064,983 (from NCBI)

This gene has 9 transcripts (splice variants), 240 orthologues and 26 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.5) and 25 other tissues.

Summary

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (CLK) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

PRPF4B Products(1)

mRNA	Protein	Name
NM_003913.5	NP_003904.3	serine/threonine-protein kinase PRP4 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15452250	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10799319	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of hippo signaling	IDA IDA: Inferred from direct assay	29695716	GOA
involved in positive regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	29695716	GOA
involved in regulation of mitotic cell cycle spindle assembly checkpoint	IDA IDA: Inferred from direct assay	17998396	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	12077342	GOA
involved in spliceosomal tri-snRNP complex assembly	IDA IDA: Inferred from direct assay	20118938	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	17998396	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	12077342	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	29695716	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20118938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPF4B Protein Structure

Pkinase

0
200
400
600
800
1007 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PRP4 homolog

PRP4 kinase

PRPF4B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRP4K	Q13523	KLF13	Homo sapiens	Q9Y2Y9	Imaging	17513757
Intra	PRP4K	Q13523	KLF13	Homo sapiens	Q9Y2Y9	Anti Bait CoIP	17513757
Intra	PRP4K	Q13523	KLF13	Homo sapiens	Q9Y2Y9	Y2H	17513757
Cross	PRP4K	Q13523	gag	Human immunodeficiency virus	P04590	Protein Kinase Assay	15452250
Cross	PRP4K	Q13523	gag	Human immunodeficiency virus	P04590	Anti Tag CoIP	15452250
Cross	PRP4K	Q13523	gag	Human immunodeficiency virus	P04590	Pull Down	15452250

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11214	PRPF4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRPF4B	VGNC	VGNC:64377
Canis familiaris	PRPF4B	VGNC	VGNC:45028
Rattus norvegicus	PRPF4B	RGD	RGD:1307784
Bos taurus	PRPF4B	VGNC	VGNC:33381
Macaca mulatta	PRPF4B	VGNC	VGNC:76276
Mus musculus	PRPF4B	MGD	MGI:109584
Others	PRPF4B	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.