2. Gene
  3. PRPF4B - pre-mRNA processing factor 4B Gene

PRPF4B - pre-mRNA processing factor 4B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PR4H; PRP4; PRP4H; PRP4K; dJ1013A10.1

Gene ID: 8899 | Gene type: protein coding

About PRPF4B

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:4,021,300-4,064,983 (from NCBI)

This gene has 9 transcripts (splice variants), 240 orthologues and 26 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.5) and 25 other tissues.

Summary

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (CLK) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

PRPF4B Products(1)

mRNA Protein Name
NM_003913.5 NP_003904.3 serine/threonine-protein kinase PRP4 homolog
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15452250 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10799319 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of hippo signaling IDA
IDA: Inferred from direct assay
29695716 GOA
involved in positive regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
29695716 GOA
involved in regulation of mitotic cell cycle spindle assembly checkpoint IDA
IDA: Inferred from direct assay
17998396 GOA
involved in spliceosomal snRNP assembly IDA
IDA: Inferred from direct assay
12077342 GOA
involved in spliceosomal tri-snRNP complex assembly IDA
IDA: Inferred from direct assay
20118938 GOA
Cellular Component GO Annotation Evidence Reference Source
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
17998396 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
12077342 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
29695716 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20118938 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPF4B Protein Structure

Pkinase

Pkinase: Protein kinase domain (691 - 1003)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1007 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PRP4 homolog

PRP4 kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11214 PRPF4B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PRPF4B VGNC VGNC:64377
Canis familiaris PRPF4B VGNC VGNC:45028
Rattus norvegicus PRPF4B RGD RGD:1307784
Bos taurus PRPF4B VGNC VGNC:33381
Macaca mulatta PRPF4B VGNC VGNC:76276
Mus musculus PRPF4B MGD MGI:109584
Others PRPF4B NCBI