RAB29 - RAB29, member RAS oncogene family Gene

Homo sapiens

Also known as RAB7L; RAB7L1

Gene ID: 8934 | Gene type: protein coding

About RAB29

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,767,986-205,775,482 (from NCBI)

This gene has 9 transcripts (splice variants), 170 orthologues and 68 paralogues. Broad expression in kidney (RPKM 27.5), thyroid (RPKM 17.1) and 24 other tissues.

Summary

Enables several functions, including dynein complex binding activity; guanyl ribonucleotide binding activity; and Kinesin binding activity. Involved in several processes, including positive regulation of T cell receptor signaling pathway; positive regulation of receptor recycling; and toxin transport. Located in several cellular components, including Golgi apparatus; endosome; and vacuole. [provided by Alliance of Genome Resources, Apr 2022]

RAB29 Products(4)

mRNA	Protein	Name
NM_001135662.2	NP_001129134.1	ras-related protein Rab-7L1 isoform 1
NM_001135663.2	NP_001129135.1	ras-related protein Rab-7L1 isoform 2
NM_001135664.2	NP_001129136.1	ras-related protein Rab-7L1 isoform 3
NM_003929.3	NP_003920.1	ras-related protein Rab-7L1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	24510904	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	24510904	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	26021297	GOA
enables kinesin binding	IPI IPI: Inferred from physical interaction	26021297	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24510904	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	26021297	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	24510904	GOA
involved in T cell activation	IMP IMP: Inferred from mutant phenotype	26021297	GOA
involved in cellular detoxification	IMP IMP: Inferred from mutant phenotype	22042847	GOA
NOT involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	24788816	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	25767741	GOA
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	19376974	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	24510904	GOA
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26021297	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	24788816	GOA
involved in positive regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	26021297	GOA
involved in protein localization to membrane	IMP IMP: Inferred from mutant phenotype	25767741	GOA
involved in response to bacterium	IDA IDA: Inferred from direct assay	22042847	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	24788816	GOA
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	26021297	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	22042847	GOA
located in cis-Golgi network	IDA IDA: Inferred from direct assay	26021297	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24788816	GOA
located in early endosome	IDA IDA: Inferred from direct assay	26021297	GOA
located in intracellular vesicle	IDA IDA: Inferred from direct assay	26021297	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25767741	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	26021297	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	24510904	GOA
located in vacuole	IDA IDA: Inferred from direct assay	22042847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB29 Protein Structure

Ras

0
100
203 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-7L1

RAB7, member RAS oncogene family-like 1

RAB29 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB29	O14966	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	RAB29	O14966	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	RAB29	O14966	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	RAB29	O14966	LRRK2	Homo sapiens	Q5S007	Pull Down	31552791
Intra	RAB29	O14966	LRRK2	Homo sapiens	Q5S007	Confocal	24510904
Intra	RAB29	O14966	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	24510904
Intra	RAB29	O14966	LRRK2	Homo sapiens	Q5S007	FPS	31552791
Intra	RAB29	O14966	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
Intra	RAB29	O14966	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	RAB29	O14966	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	RAB29	O14966	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	RAB29	O14966	LDOC1	Homo sapiens	O95751	Validated Y2H	32296183
Intra	RAB29	O14966	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
Intra	RAB29	O14966	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	RAB29	O14966	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	32296183
Intra	RAB29	O14966	TRIM32	Homo sapiens	Q13049	Validated Y2H	32296183
Intra	RAB29	O14966	TRIM32	Homo sapiens	Q13049	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Parkinson Disease 21

PARK21	Parkinson'S Disease 21
Parkinson Disease, Type 21

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Kufor-Rakeb Syndrome

Park9	Krppd
KRS	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia
Autosomal Recessive Parkinson Disease 9	Parkinson Disease 9
Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset	Autosomal Recessive Juvenile Onset Parkinson Disease 9
Parkinson Disease Type 9	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia
Park 9	Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis
Cln12 Disease	Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis
Parkinson Disease Autosomal Recessive 9

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11540	RAB29 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB29	RGD	RGD:620892
Mus musculus	RAB29	MGD	MGI:2385107
Macaca mulatta	RAB29	VGNC	VGNC:81528
Canis familiaris	RAB29	VGNC	VGNC:45270
Bos taurus	RAB29	VGNC	VGNC:33636
Felis catus	RAB29	VGNC	VGNC:97586
Others	RAB29	NCBI

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