WNT3A - Wnt family member 3A Gene

Homo sapiens

Gene ID: 89780 | Gene type: protein coding

About WNT3A

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,006,998-228,061,271 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues, 18 paralogues and is associated with 1 phenotype. Biased expression in placenta (RPKM 9.0), lung (RPKM 1.6) and 1 other tissue.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another Wnt gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]

WNT3A Products(1)

mRNA	Protein	Name
NM_033131.4	NP_149122.1	protein Wnt-3a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables co-receptor binding	IPI IPI: Inferred from physical interaction	20093360	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19072540	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	19736317	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	20093360	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16890161	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	26902720	GOA
involved in cardiac muscle cell fate commitment	IDA IDA: Inferred from direct assay	20559569	GOA
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	26902720	GOA
involved in heart development	IDA IDA: Inferred from direct assay	19736317	GOA
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	20137080	GOA
acts upstream of positive regulation of cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	20559569	GOA
involved in positive regulation of dermatome development	IDA IDA: Inferred from direct assay	10654605	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	26687115	GOA
involved in positive regulation of mesodermal cell fate specification	IDA IDA: Inferred from direct assay	20559569	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20723538	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20137080	GOA
involved in positive regulation of receptor internalization	IDA IDA: Inferred from direct assay	16890161	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20723538	GOA
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	19883499	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	19883499	GOA
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	18986540	GOA
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	18986540	GOA
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	18413325	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Wnt-Frizzled-LRP5/6 complex	IDA IDA: Inferred from direct assay	20093360	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	26902720	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18986540	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18986540	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT3A Protein Structure

wnt

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

protein Wnt-3a

wingless-type MMTV integration site family, member 3A

WNT3A Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WNT3A	P56704	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	22784633
Intra	WNT3A	P56704	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	33961781
Intra	WNT3A	P56704	WLS	Homo sapiens	Q5T9L3	IF	24768165
Intra	WNT3A	P56704	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	24768165
Intra	WNT3A	P56704	FZD8	Homo sapiens	Q9H461	Pull Down	22682250
Intra	WNT3A	P56704	LRP6	Homo sapiens	O75581	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WNT3A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70453A	Wnt3a Protein, Human (His)	P56704-1 (S19-C351)	≥95%

WNT3A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83724	Wnt3a Antibody	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases

Alias

Osteoporosis, Juvenile

Idiopathic Juvenile Osteoporosis	Idiopathic Osteoporosis
Juvenile Osteoporosis	Ijo

Hypotrichosis Simplex

Hereditary Hypotrichosis Simplex

Hhs

Hypotrichosis

Craniodiaphyseal Dysplasia, Autosomal Dominant

CDD	Autosomal Dominant Craniodiaphyseal Dysplasia
Schaefer Stein Oshman Syndrome	Craniodiaphyseal Dysplasia Autosomal Dominant

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Severe Congenital Neutropenia

Congenital Neutropenia	Neutropenia, Severe Congenital
Congenital Agranulocytosis	Infantile Genetic Agranulocytosis
Kostmann Disease	Kostmann'S Agranulocytosis
Kostmann'S Syndrome	Severe Infantile Genetic Neutropenia

Osteoporosis-Pseudoglioma Syndrome

OPPG	Ops
Osteoporosis With Pseudoglioma	Osteogenesis Imperfecta, Ocular Form
Ocular Form Of Osteogenesis Imperfecta	Osteogenesis Imperfecta Ocular Form
Osteoporosis Pseudoglioma Syndrome	Pseudoglioma With Bone Fragility

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Focal Dermal Hypoplasia

Goltz Syndrome	Goltz-Gorlin Syndrome
FDH	FODH
Dhof	Goltz Gorlin Syndrome
Hypoplasia, Dermal, Focal

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Sclerosteosis

Cortical Hyperostosis With Syndactyly	Sost
Cortical Hyperostosis-Syndactyly Syndrome

Van Buchem Disease

Hyperostosis Corticalis Generalisata	Hyperphosphatasemia Tarda
VBCH	Sost-Related Sclerosing Bone Dysplasia
Endosteal Hyperostosis Autosomal Recessive	Sclerosteosis
Endosteal Hyperostosis, Autosomal Recessive	Hyperotosis Corticalis Generalisata Familiaris
Sost Sclerosing Bone Dysplasia	Smith-Lemli-Opitz Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Scoliosis

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

Brittle Bone Disorder

Osteogenesis Imperfecta	Brittle Bone Disease
Fragilitas Ossium	Osteopsathyrosis
Lobstein Disease	Oi
Vrolik Disease	Lobstein'S Disease
Lobstein'S Syndrome	Vrolik'S Disease
Porak And Durante Disease	Glass Bone Disease
Osteogenesis Imperfecta, Dominant Perinatal Lethal	Osteogenesis Imperfecta, Recessive Perinatal Lethal
Brittle Bone Syndrome	Oi - [Osteogenesis Imperfecta]
Ossium Fragility	Osteitis Fragilitans
Bony Fragility	Blue Sclera With Fragility Of Bone And Deafness
White Blue Sclera - Fragility Of Bone - Deafness

Orofacial Cleft

Cleft, Orofacial

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect Inhibitor Pre-designed Sets	Purity	Rare Diseases Unkown
HY-129079A	TFMB-(S)-2-HG	Inhibitor	99.62%	Unkown
HY-153855	Zamaporvint	Inhibitor	99.76%	Unkown
HY-122832	ABC99	Inhibitor	99.62%	Unkown
HY-160709	Wnt/β-catenin-IN-2	Inhibitor	/	Unkown
HY-P10204	FZD7 antagonist 1		/	Unkown
HY-RS15835	WNT3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WNT3A	MGD	MGI:98956
Macaca mulatta	WNT3A	VGNC	VGNC:106529
Canis familiaris	WNT3A	VGNC	VGNC:54800
Bos taurus	WNT3A	VGNC	VGNC:52903
Rattus norvegicus	WNT3A	RGD	RGD:1308057
Felis catus	WNT3A	VGNC	VGNC:102362
Others	WNT3A	NCBI