COIL - coilin Gene

Homo sapiens

Also known as CLN80; p80-coilin

Gene ID: 8161 | Gene type: protein coding

About COIL

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,938,199-56,961,050 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Broad expression in testis (RPKM 65.0), thyroid (RPKM 8.3) and 22 other tissues.

Summary

The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]

COIL Products(1)

mRNA	Protein	Name
NM_004645.3	NP_004636.1	coilin

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12757932	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	12757932	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12757932	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12757932	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19734146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

coilin

coilin p80

COIL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COIL	P38432	ZNF277	Homo sapiens	Q8WWA6	Y2H Array	25416956
Intra	COIL	P38432	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	COIL	P38432	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	COIL	P38432	SPANXN2	Homo sapiens	Q5MJ10	Validated Y2H	32296183
Intra	COIL	P38432	ADAMTS12	Homo sapiens	P58397-3	Validated Y2H	32296183
Intra	COIL	P38432	PDE4D	Homo sapiens	Q08499	Y2H Prey Pooling	25416956
Intra	COIL	P38432	PDE4D	Homo sapiens	Q08499	Validated Y2H	25416956
Intra	COIL	P38432	VRK1	Homo sapiens	Q99986	Anti Tag CoIP	21920476
Intra	COIL	P38432	VRK1	Homo sapiens	Q99986	Peptide Array	21920476
Intra	COIL	P38432	VRK1	Homo sapiens	Q99986	Confocal	21920476
Intra	COIL	P38432	ANKS1B	Homo sapiens	Q7Z6G8-2	Anti Tag CoIP	15862129
Intra	COIL	P38432	ANKS1B	Homo sapiens	Q7Z6G8-2	Pull Down	15862129
Intra	COIL	P38432	ANKS1B	Homo sapiens	Q7Z6G8-1	Anti Bait CoIP	15862129
Intra	COIL	P38432	ANKS1B	Homo sapiens	Q7Z6G8-1	Pull Down	15862129
Intra	COIL	P38432	DYNC2I2	Homo sapiens	Q96EX3	Validated Y2H	25416956
Intra	COIL	P38432	ARMCX1	Homo sapiens	Q9P291	Validated Y2H	25416956
Intra	COIL	P38432	ARMCX1	Homo sapiens	Q9P291	Y2H Array	25416956
Intra	COIL	P38432	AK6	Homo sapiens	Q9Y3D8	Anti Tag CoIP	16079131
Intra	COIL	P38432	AK6	Homo sapiens	Q9Y3D8	Y2H	16079131
Intra	COIL	P38432	AK6	Homo sapiens	Q9Y3D8	Pull Down	16079131
Intra	COIL	P38432	C9orf72	Homo sapiens	Q96LT7	Validated Y2H	32296183
Intra	COIL	P38432	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	COIL	P38432	XRCC6	Homo sapiens	P12956	Pull Down	21070772
Intra	COIL	P38432	PSME3	Homo sapiens	P61289	Y2H Array	16713569
Intra	COIL	P38432	PSME3	Homo sapiens	P61289	Validated Y2H	32296183
Intra	COIL	P38432	PSME3	Homo sapiens	P61289	Y2H	16713569
Intra	COIL	P38432	SNRPF	Homo sapiens	P62306	Validated Y2H	32296183
Intra	COIL	P38432	SNRPF	Homo sapiens	P62306	Y2H Array	25416956
Intra	COIL	P38432	XRCC5	Homo sapiens	P13010	Pull Down	21070772
Intra	COIL	P38432	XRCC5	Homo sapiens	P13010	Competition Binding	21070772
Intra	COIL	P38432	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	COIL	P38432	POLR2L	Homo sapiens	P62875	Validated Y2H	25416956
Intra	COIL	P38432	POLR2L	Homo sapiens	P62875	Y2H Array	25416956
Intra	COIL	P38432	NKAPD1	Homo sapiens	Q6ZUT1	Validated Y2H	32296183
Intra	COIL	P38432	SMN1	Homo sapiens	Q16637	Anti Bait CoIP	21072240
Intra	COIL	P38432	SMN1	Homo sapiens	Q16637	Pull Down	21070772
Intra	COIL	P38432	POLR3C	Homo sapiens	Q9BUI4	Validated Y2H	32296183
Intra	COIL	P38432	SRPK2	Homo sapiens	P78362	Validated Y2H	32296183
Intra	COIL	P38432	FGF12	Homo sapiens	P61328	Y2H Prey Pooling	25416956
Intra	COIL	P38432	PTS	Homo sapiens	Q03393	Y2H Array	25416956
Intra	COIL	P38432	PTS	Homo sapiens	Q03393	Y2H Prey Pooling	25416956
Intra	COIL	P38432	PTS	Homo sapiens	Q03393	Validated Y2H	25416956
Intra	COIL	P38432	DRG1	Homo sapiens	Q9Y295	Y2H Array	25416956
Intra	COIL	P38432	NFU1	Homo sapiens	Q9UMS0	Validated Y2H	32296183
Intra	COIL	P38432	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	16713569
Intra	COIL	P38432	CEP70	Homo sapiens	Q8NHQ1	Y2H	16713569
Intra	COIL	P38432	LNX1	Homo sapiens	Q8TBB1	Pull Down	16713569
Intra	COIL	P38432	PDLIM5	Homo sapiens	Q96HC4	Y2H Array	31515488
Intra	COIL	P38432	PDLIM5	Homo sapiens	Q96HC4	Y2H Prey Pooling	25416956
Intra	COIL	P38432	PDLIM5	Homo sapiens	Q96HC4	Y2H Array	25416956
Intra	COIL	P38432	PICK1	Homo sapiens	Q9NRD5	Y2H	16713569
Intra	COIL	P38432	PDE4D	Homo sapiens	Q08499-8	Validated Y2H	32296183
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	COIL	P38432	ATXN1	Homo sapiens	P54253-1	IF	12757932

Cross: Cross-species interaction Intra: Intraspecies interaction

COIL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82787	Coilin Antibody (YA2532)	WB	Human

Related Diseases

Diseases

Alias

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Actinomycosis

Actinomycetoma	Boil
Canaliculitis	Actinomycotic Infection
Actinomycotic Madura Foot	Keratoactinomycosis
Furuncle	Actinomycotic Mycetema
Actinomycotic Mycetoma Of Foot	Madura Foot Due To Actinomadura
Actinomyces Israeli	Actinomycetes
Anaerobic Actinomyces Infection	Actinomycotic Infection Of Unspecified Site
Actinomycosis Nos	Actinomycotic Node
Actinomyces Infection	Actinomycotic Mycetoma
Mycetoma Due To Filamentous Bacteria

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Differentiating Neuroblastoma

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148808	Zelasudil	Inhibitor	99.86%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10996A	KHS101 hydrochloride		99.84%	Unkown
HY-135960	BO-264		99.63%	Unkown
HY-18990	GSK180736A	Inhibitor	98.81%	Unkown
HY-118046	GSK2163632A	Inhibitor	/	Unkown
HY-118837	WF-536	Inhibitor	/	Unkown
HY-150536	EP39	Inhibitor	/	Unkown
HY-P10820	N36Mut(e,g)	Inhibitor	/	Unkown
HY-RS02958	COIL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COIL	RGD	RGD:62031
Felis catus	COIL	VGNC	VGNC:61051
Mus musculus	COIL	MGD	MGI:104842
Bos taurus	COIL	VGNC	VGNC:27552
Canis familiaris	COIL	VGNC	VGNC:39454
Others	COIL	NCBI

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