TAF1C - TATA-box binding protein associated factor, RNA polymerase I subunit C Gene

Homo sapiens

Also known as SL1; TAFI95; TAFI110; MGC:39976

Gene ID: 9013 | Gene type: protein coding

About TAF1C

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,177,855-84,187,057 (from NCBI)

This gene has 23 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in spleen (RPKM 19.0), ovary (RPKM 12.6) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

TAF1C Products(7)

mRNA	Protein	Name
NM_001243156.2	NP_001230085.2	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 3
NM_001243157.2	NP_001230086.1	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 4
NM_001243158.2	NP_001230087.1	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 4
NM_001243159.2	NP_001230088.1	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 5
NM_001243160.2	NP_001230089.1	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 6
NM_005679.4	NP_005670.4	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1
NM_139353.3	NP_647610.3	TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase I core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22368283	GOA
enables RNA polymerase I general transcription initiation factor activity	IDA IDA: Inferred from direct assay	12498690	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11250903	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase transcription factor SL1 complex	IDA IDA: Inferred from direct assay	11250903	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12498690	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TATA box-binding protein-associated factor RNA polymerase I subunit C

RNA polymerase I-specific TBP-associated factor 110 kDa

TAF1C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAF1C	Q15572	TAF12	Homo sapiens	Q16514	Pull Down	17268553
Intra	TAF1C	Q15572	SET	Homo sapiens	Q01105	Affinity Techniques	17318177
Intra	TAF1C	Q15572	SET	Homo sapiens	Q01105	Anti Tag CoIP	17318177
Intra	TAF1C	Q15572	SET	Homo sapiens	Q01105	Pull Down	17318177
Intra	TAF1C	Q15572	TAF1B	Homo sapiens	Q53T94	Anti Tag CoIP	33961781
Intra	TAF1C	Q15572	TAF1B	Homo sapiens	Q53T94	Anti Tag CoIP	17318177
Intra	TAF1C	Q15572	TBP	Homo sapiens	P20226	Pull Down	17318177
Intra	TAF1C	Q15572	TBP	Homo sapiens	P20226	Anti Bait CoIP	17268553

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14164	TAF1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TAF1C	VGNC	VGNC:47079
Macaca mulatta	TAF1C	VGNC	VGNC:78089
Felis catus	TAF1C	VGNC	VGNC:82313
Mus musculus	TAF1C	MGD	MGI:109576
Bos taurus	TAF1C	VGNC	VGNC:35571
Rattus norvegicus	TAF1C	RGD	RGD:1305658

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