TAF12 - TATA-box binding protein associated factor 12 Gene

Homo sapiens

Also known as TAF2J; TAFII20

Gene ID: 6883 | Gene type: protein coding

About TAF12

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,602,850-28,648,269 (from NCBI)

This gene has 17 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in testis (RPKM 9.9), lymph node (RPKM 8.4) and 25 other tissues.

Summary

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas Others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while Others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]

TAF12 Products(3)

mRNA	Protein	Name
NM_001135218.2	NP_001128690.1	transcription initiation factor TFIID subunit 12 isoform 1
NM_001410769.1	NP_001397698.1	transcription initiation factor TFIID subunit 12 isoform 2
NM_005644.4	NP_005635.1	transcription initiation factor TFIID subunit 12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15601843	GOA
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	17264123	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17264123	GOA
contributes to RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	9603525	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7667268	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11564863	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	9603525	GOA
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17264123	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	9603525	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SAGA complex	IDA IDA: Inferred from direct assay	9674425	GOA
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11564863	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	14580349	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	9603525	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF12 Protein Structure

TFIID_20kDa

0
100
161 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor TFIID subunit 12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

TAF12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TAF12	Q16514	PRKAR2B	Homo sapiens	Q6DHZ2	Y2H Array	25416956
Intra	TAF12	Q16514	PRKAR2B	Homo sapiens	Q6DHZ2	Y2H Prey Pooling	25416956
Intra	TAF12	Q16514	TAF4	Homo sapiens	O00268	Anti Tag CoIP	33961781
Intra	TAF12	Q16514	TAF4	Homo sapiens	O00268	X-Ray Diffraction	12237304
Intra	TAF12	Q16514	TAF4	Homo sapiens	O00268	Anti Tag CoIP	35271311
Intra	TAF12	Q16514	TAF1C	Homo sapiens	Q15572	Anti Bait CoIP	17268553
Intra	TAF12	Q16514	TBP	Homo sapiens	P20226	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Choroid Plexus Cancer

Choroid Plexus Carcinoma	Choroid Plexus Neoplasms
Choroid Plexus Neoplasm	Tumor Of Choroid Plexus
Tumor Of The Choroid Plexus	Choroid Plexus Tumor
Choroid Plexus Tumors	Anaplastic Choroid Plexus Papilloma
Choroid Plexus Papilloma Nos	Papilloma Of Choroid Plexus
Plexus Choroideus Papilloma	Choroid Plexus Papilloma In Fourth Ventricle
Plexus Choroideus Papilloma In Fourth Ventricle

Atypical Choroid Plexus Papilloma

Atypical Papilloma Of Choroid Plexus

Atypical Cpp

Cerebrovascular Benign Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112803	GNE-371		98.21%	Unkown
HY-RS14160	TAF12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TAF12	VGNC	VGNC:106512
Felis catus	TAF12	VGNC	VGNC:65925
Bos taurus	TAF12	VGNC	VGNC:97316
Rattus norvegicus	TAF12	RGD	RGD:1592841
Mus musculus	TAF12	MGD	MGI:1913714

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