KLHL13 - kelch like family member 13 Gene

Homo sapiens

Also known as BKLHD2

Gene ID: 90293 | Gene type: protein coding

About KLHL13

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:117,897,813-118,131,050 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 54 paralogues. Broad expression in endometrium (RPKM 9.9), kidney (RPKM 3.7) and 15 other tissues.

Summary

This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and Other proteins to form the Cullin 3-based E3 ubiquitin-protein Ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

KLHL13 Products(9)

mRNA	Protein	Name
NM_001168299.2	NP_001161771.1	kelch-like protein 13 isoform b
NM_001168300.2	NP_001161772.1	kelch-like protein 13 isoform c
NM_001168301.2	NP_001161773.1	kelch-like protein 13 isoform d
NM_001168302.2	NP_001161774.1	kelch-like protein 13 isoform d
NM_001168303.4	NP_001161775.2	kelch-like protein 13 isoform e
NM_001394863.1	NP_001381792.1	kelch-like protein 13 isoform a
NM_001394864.1	NP_001381793.1	kelch-like protein 13 isoform f
NM_001394866.1	NP_001381795.1	kelch-like protein 13 isoform g
NM_033495.4	NP_277030.2	kelch-like protein 13 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14528312	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17543862	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	17543862	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	17543862	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14528312	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL13 Protein Structure

BTB

BACK

Kelch_1

0
200
400
600
655 a.a.

Protein Preferred Names

Protein Names

kelch-like protein 13

BTB and kelch domain containing 2

KLHL13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLHL13	Q9P2N7	CUL3	Homo sapiens	Q13618	Anti Bait CoIP	17543862
Intra	KLHL13	Q9P2N7	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	21145461
Intra	KLHL13	Q9P2N7	CUL3	Homo sapiens	Q13618	TAP	21145461
Intra	KLHL13	Q9P2N7	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	30190310
Intra	KLHL13	Q9P2N7	AURKB	Homo sapiens	Q96GD4	Anti Bait CoIP	17543862

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07357	KLHL13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KLHL13	VGNC	VGNC:63143
Mus musculus	KLHL13	MGD	MGI:1914705
Bos taurus	KLHL13	VGNC	VGNC:30643
Canis familiaris	KLHL13	VGNC	VGNC:42449
Rattus norvegicus	KLHL13	RGD	RGD:1559646
Macaca mulatta	KLHL13	VGNC	VGNC:74105

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