2. Gene
  3. CUL3 - cullin 3 Gene

CUL3 - cullin 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CUL-3; PHA2E; NEDAUS

Gene ID: 8452 | Gene type: protein coding

About CUL3

Cytogenetic location: 2q36.2 Genomic coordinates (GRCh38): 2:224,470,150-224,585,363 (from NCBI)

This gene has 15 transcripts (splice variants), 293 orthologues, 7 paralogues and is associated with 77 phenotypes. Broad expression in testis (RPKM 53.6), esophagus (RPKM 12.6) and 24 other tissues.

Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin Ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

CUL3 Products(3)

mRNA Protein Name
NM_001257197.2 NP_001244126.1 cullin-3 isoform 2
NM_001257198.2 NP_001244127.1 cullin-3 isoform 3
NM_003590.5 NP_003581.1 cullin-3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Notch binding IPI
IPI: Inferred from physical interaction
25401743 GOA
enables POZ domain binding IDA
IDA: Inferred from direct assay
14528312 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12609982 GOA
enables ubiquitin ligase complex scaffold activity IDA
IDA: Inferred from direct assay
23453970 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
14528312 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
14528312 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
15983046 GOA
Biological Process GO Annotation Evidence Reference Source
involved in COPII vesicle coating IMP
IMP: Inferred from mutant phenotype
22358839 GOA
acts upstream of or within anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
10500095 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
19782033 GOA
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
29769719 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: Inferred from direct assay
22358839 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
17543862 GOA
involved in negative regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
19782033 GOA
involved in negative regulation of type I interferon production IDA
IDA: Inferred from direct assay
36394357 GOA
involved in nuclear protein quality control by the ubiquitin-proteasome system IDA
IDA: Inferred from direct assay
27561354 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
29769719 GOA
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
19261606 GOA
involved in positive regulation of mitotic cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
23213400 GOA
involved in positive regulation of mitotic metaphase/anaphase transition IMP
IMP: Inferred from mutant phenotype
17543862 GOA
involved in positive regulation of protein ubiquitination IGI
IGI: Inferred from genetic interaction
24844779 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19261606 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
25684205 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
25684205 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
14528312 GOA
involved in protein destabilization IGI
IGI: Inferred from genetic interaction
24844779 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
22358839 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
14528312 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
17543862 GOA
involved in regulation of cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
27708159 GOA
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
19782033 GOA
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
25401743 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
27561354 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
14528312 GOA
located in centrosome IDA
IDA: Inferred from direct assay
23213400 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
27708159 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
28395323 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
23213400 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23213400 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19617556 GOA
located in polar microtubule IDA
IDA: Inferred from direct assay
19995937 GOA
located in sperm flagellum IDA
IDA: Inferred from direct assay
28395323 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
23213400 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL3 Protein Structure

Cullin

Cullin: Cullin family (34 - 666)

Cullin_Nedd8

Cullin_Nedd8: Cullin protein neddylation domain (695 - 761)

  • 0
  • 200
  • 400
  • 600
  • 768 a.a.
Protein Preferred Names Protein Names

cullin-3

CUL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CUL3 Q13618 ZMAT4 Homo sapiens Q9H898-2
Validated Y2H
32296183
Intra CUL3 Q13618 ZMAT4 Homo sapiens Q9H898-2
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 ZMAT4 Homo sapiens Q9H898-2
Y2H Array
32296183
Intra CUL3 Q13618 KCTD7 Homo sapiens Q96MP8-2
Y2H Array
32296183
Intra CUL3 Q13618 KCTD7 Homo sapiens Q96MP8-2
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 KCTD7 Homo sapiens Q96MP8-2
Validated Y2H
32296183
Intra CUL3 Q13618 BTBD6 Homo sapiens Q96KE9-2
Validated Y2H
32296183
Intra CUL3 Q13618 BTBD6 Homo sapiens Q96KE9-2
Y2H Array
32296183
Intra CUL3 Q13618 BTBD6 Homo sapiens Q96KE9-2
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 KLHL13 Homo sapiens Q9P2N7
TAP
21145461
Intra CUL3 Q13618 KLHL13 Homo sapiens Q9P2N7
Anti Tag CoIP
30190310
Intra CUL3 Q13618 KLHL13 Homo sapiens Q9P2N7
Anti Bait CoIP
17543862
Intra CUL3 Q13618 KLHL13 Homo sapiens Q9P2N7
Anti Tag CoIP
34591642
Intra CUL3 Q13618 KLHL13 Homo sapiens Q9P2N7
Pull Down
17543862
Intra CUL3 Q13618 KLHL13 Homo sapiens Q9P2N7
Anti Bait CoIP
30190310
Intra CUL3 Q13618 KBTBD8 Homo sapiens Q8NFY9
TAP
21145461
Intra CUL3 Q13618 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
25416956
Intra CUL3 Q13618 TNFAIP1 Homo sapiens Q13829
Anti Tag CoIP
34591642
Intra CUL3 Q13618 TNFAIP1 Homo sapiens Q13829
TAP
21145461
Intra CUL3 Q13618 TNFAIP1 Homo sapiens Q13829
Anti Tag CoIP
33961781
Intra CUL3 Q13618 KCTD10 Homo sapiens Q9H3F6
Anti Tag CoIP
33961781
Intra CUL3 Q13618 KCTD10 Homo sapiens Q9H3F6
TAP
21145461
Intra CUL3 Q13618 KCTD10 Homo sapiens Q9H3F6
Anti Tag CoIP
34591642
Intra CUL3 Q13618 KCTD10 Homo sapiens Q9H3F6
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 KCTD10 Homo sapiens Q9H3F6
Validated Y2H
32296183
Intra CUL3 Q13618 KCTD10 Homo sapiens Q9H3F6
Y2H Array
32296183
Intra CUL3 Q13618 KLHL9 Homo sapiens Q9P2J3
Anti Tag CoIP
30190310
Intra CUL3 Q13618 KLHL9 Homo sapiens Q9P2J3
Anti Bait CoIP
17543862
Intra CUL3 Q13618 KLHL9 Homo sapiens Q9P2J3
Anti Tag CoIP
34591642
Intra CUL3 Q13618 KLHL9 Homo sapiens Q9P2J3
Pull Down
17543862
Intra CUL3 Q13618 KLHL9 Homo sapiens Q9P2J3
TAP
21145461
Intra CUL3 Q13618 KCTD6 Homo sapiens Q8NC69
Y2H Prey Pooling
25416956
Intra CUL3 Q13618 KCTD6 Homo sapiens Q8NC69
TAP
21145461
Intra CUL3 Q13618 KCTD6 Homo sapiens Q8NC69
Validated Y2H
25416956
Intra CUL3 Q13618 KCTD6 Homo sapiens Q8NC69
Validated Y2H
32296183
Intra CUL3 Q13618 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra CUL3 Q13618 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 GMCL1 Homo sapiens Q96IK5
Y2H Array
31515488
Intra CUL3 Q13618 GMCL1 Homo sapiens Q96IK5
TAP
21145461
Intra CUL3 Q13618 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra CUL3 Q13618 ZMAT4 Homo sapiens Q9H898
Y2H Prey Pooling
25416956
Intra CUL3 Q13618 KLHL5 Homo sapiens Q96PQ7
Y2H
21988832
Intra CUL3 Q13618 KLHL5 Homo sapiens Q96PQ7
TAP
21145461
Intra CUL3 Q13618 KLHL5 Homo sapiens Q96PQ7
Anti Tag CoIP
34591642
Intra CUL3 Q13618 ELOC Homo sapiens Q15369
Y2H Array
21988832
Intra CUL3 Q13618 ELOC Homo sapiens Q15369
TAP
21145461
Intra CUL3 Q13618 BTBD3 Homo sapiens Q9Y2F9
Validated Y2H
32296183
Intra CUL3 Q13618 BTBD3 Homo sapiens Q9Y2F9
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 BTBD3 Homo sapiens Q9Y2F9
Y2H Array
32296183
Intra CUL3 Q13618 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra CUL3 Q13618 HSP90AB1 Homo sapiens P08238
Anti Bait CoIP
37207277
Intra CUL3 Q13618 HSP90AB1 Homo sapiens P08238
TAP
21145461
Intra CUL3 Q13618 CKB Homo sapiens P12277
Anti Bait CoIP
37207277
Intra CUL3 Q13618 CKB Homo sapiens P12277
TAP
21145461
Intra CUL3 Q13618 CCDC22 Homo sapiens O60826
Pull Down
23563313
Intra CUL3 Q13618 RBX1 Homo sapiens P62877
Anti Tag CoIP
34591642
Intra CUL3 Q13618 RBX1 Homo sapiens P62877
Pull Down
17543862
Intra CUL3 Q13618 RBX1 Homo sapiens P62877
Pull Down
25619834
Intra CUL3 Q13618 RBX1 Homo sapiens P62877
GMS
37788672
Intra CUL3 Q13618 RBX1 Homo sapiens P62877
3D-EM
37788672
Intra CUL3 Q13618 KCTD9 Homo sapiens Q7L273
Validated Y2H
25416956
Intra CUL3 Q13618 KCTD9 Homo sapiens Q7L273
TAP
21145461
Intra CUL3 Q13618 KCTD9 Homo sapiens Q7L273
Validated Y2H
32296183
Intra CUL3 Q13618 KCTD9 Homo sapiens Q7L273
Y2H Array
25416956
Intra CUL3 Q13618 KCTD9 Homo sapiens Q7L273
Y2H Array
32296183
Intra CUL3 Q13618 KCTD9 Homo sapiens Q7L273
Y2H Prey Pooling
25416956
Intra CUL3 Q13618 KCTD9 Homo sapiens Q7L273
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 CAND1 Homo sapiens Q86VP6
TAP
21145461
Intra CUL3 Q13618 CAND1 Homo sapiens Q86VP6
Anti Tag CoIP
34591642
Intra CUL3 Q13618 CAND1 Homo sapiens Q86VP6
CoIP
12609982
Intra CUL3 Q13618 COPS5 Homo sapiens Q92905
Anti Bait CoIP
37207277
Intra CUL3 Q13618 COPS5 Homo sapiens Q92905
TAP
21145461
Intra CUL3 Q13618 KLHL7 Homo sapiens Q8IXQ5
TAP
21145461
Intra CUL3 Q13618 KLHL7 Homo sapiens Q8IXQ5
Anti Tag CoIP
34591642
Intra CUL3 Q13618 KLHL7 Homo sapiens Q8IXQ5
Anti Tag CoIP
33961781
Intra CUL3 Q13618 KLHL7 Homo sapiens Q8IXQ5
Anti Tag CoIP
30190310
Intra CUL3 Q13618 KLHL1 Homo sapiens Q9NR64
Pull Down
22632832
Intra CUL3 Q13618 KLHL1 Homo sapiens Q9NR64
Anti Tag CoIP
30190310
Intra CUL3 Q13618 BTBD2 Homo sapiens Q9BX70
TAP
21145461
Intra CUL3 Q13618 BTBD2 Homo sapiens Q9BX70
Validated Y2H
32296183
Intra CUL3 Q13618 BTBD2 Homo sapiens Q9BX70
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 BTBD2 Homo sapiens Q9BX70
Anti Bait CoIP
17543862
Intra CUL3 Q13618 BTBD2 Homo sapiens Q9BX70
Anti Tag CoIP
34591642
Intra CUL3 Q13618 BTBD2 Homo sapiens Q9BX70
Y2H Array
32296183
Intra CUL3 Q13618 KLHL20 Homo sapiens Q9Y2M5
Anti Tag CoIP
20389280
Intra CUL3 Q13618 KLHL20 Homo sapiens Q9Y2M5
Anti Tag CoIP
30190310
Intra CUL3 Q13618 KLHL20 Homo sapiens Q9Y2M5
Pull Down
25619834
Intra CUL3 Q13618 KLHL20 Homo sapiens Q9Y2M5
Anti Tag CoIP
34591642
Intra CUL3 Q13618 KLHL20 Homo sapiens Q9Y2M5
Pull Down
22632832
Intra CUL3 Q13618 KLHL20 Homo sapiens Q9Y2M5
TAP
21145461
Intra CUL3 Q13618 IVNS1ABP Homo sapiens Q9Y6Y0
Pull Down
25619834
Intra CUL3 Q13618 IVNS1ABP Homo sapiens Q9Y6Y0
Anti Tag CoIP
25619834
Intra CUL3 Q13618 BTBD10 Homo sapiens Q9BSF8
TAP
21145461
Intra CUL3 Q13618 BTBD10 Homo sapiens Q9BSF8
Anti Tag CoIP
33961781
Intra CUL3 Q13618 BTBD10 Homo sapiens Q9BSF8
Y2H
21988832
Intra CUL3 Q13618 BTBD10 Homo sapiens Q9BSF8
Anti Tag CoIP
34591642
Intra CUL3 Q13618 ABTB1 Homo sapiens Q969K4
Y2H Prey Pooling
25416956
Intra CUL3 Q13618 ABTB1 Homo sapiens Q969K4
TAP
21145461
Intra CUL3 Q13618 ABTB1 Homo sapiens Q969K4
Y2H Array
25416956
Intra CUL3 Q13618 ABTB1 Homo sapiens Q969K4
Y2H Array
31515488
Intra CUL3 Q13618 SHKBP1 Homo sapiens Q8TBC3
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 SHKBP1 Homo sapiens Q8TBC3
Anti Tag CoIP
34591642
Intra CUL3 Q13618 SHKBP1 Homo sapiens Q8TBC3
Y2H Array
32296183
Intra CUL3 Q13618 SHKBP1 Homo sapiens Q8TBC3
TAP
21145461
Intra CUL3 Q13618 SHKBP1 Homo sapiens Q8TBC3
Validated Y2H
32296183
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
TAP
21145461
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Anti Tag CoIP
34591642
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Validated Y2H
25416956
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Anti Bait CoIP
30190310
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Validated Y2H
32296183
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Y2H Array
25416956
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Anti Tag CoIP
30190310
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Pull Down
30190310
Intra CUL3 Q13618 KLHL12 Homo sapiens Q53G59
Anti Bait CoIP
17543862
Intra CUL3 Q13618 KCTD13 Homo sapiens Q8WZ19
Validated Y2H
32296183
Intra CUL3 Q13618 KCTD13 Homo sapiens Q8WZ19
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 KCTD13 Homo sapiens Q8WZ19
Y2H Array
32296183
Intra CUL3 Q13618 KCTD13 Homo sapiens Q8WZ19
Y2H Prey Pooling
25416956
Intra CUL3 Q13618 KCTD13 Homo sapiens Q8WZ19
Anti Tag CoIP
34591642
Intra CUL3 Q13618 KCTD13 Homo sapiens Q8WZ19
TAP
21145461
Intra CUL3 Q13618 SPOP Homo sapiens O43791
Y2H
21988832
Intra CUL3 Q13618 SPOP Homo sapiens O43791
Anti Tag CoIP
33961781
Intra CUL3 Q13618 SPOP Homo sapiens O43791
Pull Down
21577200
Intra CUL3 Q13618 SPOP Homo sapiens O43791
Pull Down
22632832
Intra CUL3 Q13618 KLHL2 Homo sapiens O95198
TAP
21145461
Intra CUL3 Q13618 KLHL2 Homo sapiens O95198
Y2H Array
31515488
Intra CUL3 Q13618 KLHL2 Homo sapiens O95198
Anti Tag CoIP
33961781
Intra CUL3 Q13618 KLHL2 Homo sapiens O95198
Validated Y2H
25416956
Intra CUL3 Q13618 KLHL2 Homo sapiens O95198
Y2H Array
25416956
Intra CUL3 Q13618 KLHL2 Homo sapiens O95198
Anti Tag CoIP
34591642
Intra CUL3 Q13618 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 KEAP1 Homo sapiens Q14145
Validated Y2H
32296183
Intra CUL3 Q13618 KEAP1 Homo sapiens Q14145
TAP
21145461
Intra CUL3 Q13618 KEAP1 Homo sapiens Q14145
Y2H Array
32296183
Intra CUL3 Q13618 CASP8 Homo sapiens Q14790
Anti Bait CoIP
19427028
Intra CUL3 Q13618 KLHL3 Homo sapiens Q9UH77
Validated Y2H
32296183
Intra CUL3 Q13618 KLHL3 Homo sapiens Q9UH77
Y2H Array
25502805
Intra CUL3 Q13618 KLHL3 Homo sapiens Q9UH77
Y2H Array
32296183
Intra CUL3 Q13618 KLHL3 Homo sapiens Q9UH77
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 KLHL3 Homo sapiens Q9UH77
Y2H Array
31515488
Intra CUL3 Q13618 BTBD1 Homo sapiens Q9H0C5
Validated Y2H
32296183
Intra CUL3 Q13618 BTBD1 Homo sapiens Q9H0C5
Y2H Array
32296183
Intra CUL3 Q13618 BTBD1 Homo sapiens Q9H0C5
Anti Bait CoIP
17543862
Intra CUL3 Q13618 BTBD1 Homo sapiens Q9H0C5
Anti Tag CoIP
34591642
Intra CUL3 Q13618 BTBD1 Homo sapiens Q9H0C5
Anti Bait CoIP
37207277
Intra CUL3 Q13618 BTBD1 Homo sapiens Q9H0C5
Y2H Prey Pooling
32296183
Intra CUL3 Q13618 BTBD1 Homo sapiens Q9H0C5
TAP
21145461
Intra CUL3 Q13618 ACOT7 Homo sapiens O00154
Crosslink
26949739
Intra CUL3 Q13618 KLHL8 Homo sapiens Q9P2G9
TAP
21145461
Intra CUL3 Q13618 KLHL8 Homo sapiens Q9P2G9
Anti Tag CoIP
33961781
Intra CUL3 Q13618 KLHL8 Homo sapiens Q9P2G9
Anti Tag CoIP
30190310
Intra CUL3 Q13618 KLHL8 Homo sapiens Q9P2G9
Anti Tag CoIP
34591642
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pseudohypoaldosteronism, Type Iie

Pseudohypoaldosteronism Type 2e

PHA2E

Familial Hyperkalemic Hypertension

Gordon'S Syndrome

Phaii

Pseudohypoaldosteronism Type 2

Gordon Hyperkalemia-Hypertension Syndrome

Pseudohypoaldosteronism Type Ii

Chloride Shunt Syndrome

Hyperpotassemia And Hypertension Familial

Pha2

Familial Hyperpotassemia And Hypertension

Familial Hypertensive Hyperkalemia

Fhht

Hyperkalemia-Hypertension Syndrome, Gordon Type

Hypertensive Hyperkalemia

Mineralocorticoid Resistant Hyperkalemia

Spitzer-Weinstein Syndrome

Pseudohypoaldosteronism 2e

Pseudohypoaldosteronism, Type Ii

Pseudohypoaldosteronism, Type Iid

Hyperpotassemia And Hypertension, Familial
Neurodevelopmental Disorder With Or Without Autism Or Seizures

NEDAUS

Neurodevelopmental Disorder With Autism Without Seizures

Neurodevelopmental Disorder Without Autism With Seizures

Neurodevelopmental Disorder Without Autism Or Seizures

Neurodevelopmental Disorder With/Without Autism Or Seizures
Pseudohypoaldosteronism, Type Iia

Pseudohypoaldosteronism Type 2a

PHA2A

Hyperpotassemia And Hypertension, Familial

Hypertensive Hyperkalemia, Familial

Gordon Hyperkalemia-Hypertension Syndrome

Pseudohypoaldosteronism, Type Ii
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Pseudohypoaldosteronism, Type I, Autosomal Dominant

Autosomal Dominant Pseudohypoaldosteronism Type 1

PHA1A

Pseudohypoaldosteronism Type I, Autosomal Dominant

Pseudohypoaldosteronism Type 1 Autosomal Dominant

Renal Pha1

Renal Pseudohypoaldosteronism Type 1

Pha I, Autosomal Dominant

Autosomal Dominant Pha 1

Pseudohypoaldosteronism Type 1, Dominant

Autosomal Dominant Pha1

Pseudohypoaldosteronism 1, Autosomal Dominant

Pha Type I, Autosomal Dominant
Pseudohypoaldosteronism
Nk-Cell Enteropathy
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Cold-Induced Sweating Syndrome 3
Metabolic Acidosis
Giant Axonal Neuropathy 2
Arthrogryposis, Distal, Type 3

Gordon Syndrome

DA3

Distal Arthrogryposis Type 3

Arthrogryposis Multiplex Congenita, Distal, Type Iia

Camptodactyly, Cleft Palate, And Clubfoot

Camptodactyly-Cleft Palate-Clubfoot Syndrome

Distal Arthrogryposis Multiplex Congenita Type Iia

Arthrogryposis Distal Type 3

Distal Arthrogryposis Type Iia

Arthrogryposis, Distal, 3

Pseudohypoaldosteronism, Type Ii
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]
Penis Carcinoma In Situ

Carcinoma In Situ Of Penis

Bowen'S Disease Of Penis

Grade Iii Squamous Intraepithelial Lesion Of Penis

Penile Intraepithelial Neoplasia Grade Iii

Queyrat'S Erythroplasia

Erythroplasia Of Queyrat

Pin - [Penile Intraepithelial Neoplasia]
Renal Tubular Transport Disease

Renal Tubular Transport, Inborn Errors

Inborn Renal Tubular Transport Disorder
Cold-Induced Sweating Syndrome

Crisponi Syndrome

Sohar-Crisponi Syndrome

Ciss

Cntf Receptor-Related Disorders

Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death

Sweating Syndrome, Cold-Induced
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome
Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126075A WS-383 Inhibitor 99.88% Unkown
HY-126075 WS-383 free base Inhibitor / Unkown
HY-124834 Nrf2 activator-10 / Unkown
HY-RS03361 CUL3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CUL3 VGNC VGNC:61284
Macaca mulatta CUL3 VGNC VGNC:71567
Canis familiaris CUL3 VGNC VGNC:39730
Mus musculus CUL3 MGD MGI:1347360
Bos taurus CUL3 VGNC VGNC:27831
Rattus norvegicus CUL3 RGD RGD:1308190
Others CUL3 NCBI