STARD13 - StAR related lipid transfer domain containing 13 Gene

Homo sapiens

Also known as DLC2; GT650; ARHGAP37; LINC00464

Gene ID: 90627 | Gene type: protein coding

About STARD13

Cytogenetic location: 13q13.1-q13.2 Genomic coordinates (GRCh38): 13:33,103,137-33,676,794 (from NCBI)

This gene has 9 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 9.3), thyroid (RPKM 7.8) and 24 other tissues.

Summary

This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

STARD13 Products(7)

mRNA	Protein	Name
NM_001243466.2	NP_001230395.1	stAR-related lipid transfer protein 13 isoform 5
NM_001243474.2	NP_001230403.1	stAR-related lipid transfer protein 13 isoform 6
NM_001243476.3	NP_001230405.1	stAR-related lipid transfer protein 13 isoform 4
NM_001411014.1	NP_001397943.1	stAR-related lipid transfer protein 13 isoform 7
NM_052851.3	NP_443083.1	stAR-related lipid transfer protein 13 isoform 3
NM_178006.4	NP_821074.1	stAR-related lipid transfer protein 13 isoform 1
NM_178007.3	NP_821075.1	stAR-related lipid transfer protein 13 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14697242	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within endothelial cell migration	IGI IGI: Inferred from genetic interaction	20208559	GOA
acts upstream of or within endothelial cell migration	IMP IMP: Inferred from mutant phenotype	20208559	GOA
acts upstream of or within endothelial tube lumen extension	IGI IGI: Inferred from genetic interaction	20208559	GOA
acts upstream of or within endothelial tube lumen extension	IMP IMP: Inferred from mutant phenotype	20208559	GOA
acts upstream of or within negative regulation of cell migration involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	20208559	GOA
acts upstream of or within negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	20208559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STARD13 Protein Structure

SAM_2

RhoGAP

START

0
200
400
600
800
1000
1113 a.a.

Protein Preferred Names

Protein Names

stAR-related lipid transfer protein 13

Rho GTPase activating protein on chromosome 13q12

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13877	STARD13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STARD13	VGNC	VGNC:65752
Mus musculus	STARD13	MGD	MGI:2385331
Macaca mulatta	STARD13	VGNC	VGNC:77962
Canis familiaris	STARD13	VGNC	VGNC:46881
Bos taurus	STARD13	VGNC	VGNC:35362
Rattus norvegicus	STARD13	RGD	RGD:1564816

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