ZFAND2A - zinc finger AN1-type containing 2A Gene

Homo sapiens

Also known as AIRAP

Gene ID: 90637 | Gene type: protein coding

About ZFAND2A

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:1,148,850-1,160,196 (from NCBI)

This gene has 7 transcripts (splice variants), 123 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 5.6), liver (RPKM 4.6) and 25 other tissues.

Summary

Predicted to enable zinc ion binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein targeting to ER. Predicted to act upstream of or within cellular response to arsenic-containing substance and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of Proteasome complex. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ZFAND2A Products(3)

mRNA	Protein	Name
NM_001365381.2	NP_001352310.1	AN1-type zinc finger protein 2A isoform 2
NM_001365383.1	NP_001352312.1	AN1-type zinc finger protein 2A isoform 3
NM_182491.4	NP_872297.2	AN1-type zinc finger protein 2A isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFAND2A Protein Structure

zf-AN1

0
100
145 a.a.

Protein Preferred Names

Protein Names

AN1-type zinc finger protein 2A

arsenite inducible RNA associated protein

ZFAND2A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFAND2A	Q8N6M9	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	ZFAND2A	Q8N6M9	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	ZFAND2A	Q8N6M9	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	ZFAND2A	Q8N6M9	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	ZFAND2A	Q8N6M9	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	ZFAND2A	Q8N6M9	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	ZFAND2A	Q8N6M9	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	ZFAND2A	Q8N6M9	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	ZFAND2A	Q8N6M9	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	ZFAND2A	Q8N6M9	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	ZFAND2A	Q8N6M9	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	ZFAND2A	Q8N6M9	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	ZFAND2A	Q8N6M9	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16029	ZFAND2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZFAND2A	MGD	MGI:2140729
Canis familiaris	ZFAND2A	VGNC	VGNC:48600
Rattus norvegicus	ZFAND2A	RGD	RGD:1310991
Bos taurus	ZFAND2A	VGNC	VGNC:37149

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