2. Gene
  3. LDB2 - LIM domain binding 2 Gene

LDB2 - LIM domain binding 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LDB1; CLIM1; LDB-2

Gene ID: 9079 | Gene type: protein coding

About LDB2

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:16,501,541-16,898,645 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 25.9), fat (RPKM 24.8) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

LDB2 Products(4)

mRNA Protein Name
NM_001130834.3 NP_001124306.1 LIM domain-binding protein 2 isoform b
NM_001290.5 NP_001281.1 LIM domain-binding protein 2 isoform a
NM_001304434.2 NP_001291363.1 LIM domain-binding protein 2 isoform c
NM_001304435.2 NP_001291364.1 LIM domain-binding protein 2 isoform d
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
9853615 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDB2 Protein Structure

LIM_bind

LIM_bind: LIM-domain binding protein (30 - 233)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

LIM domain-binding protein 2

LIM binding domain 2

LDB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra LDB2 O43679 GGACT Homo sapiens Q9BVM4
Validated Y2H
32296183
Intra LDB2 O43679 LMO3 Homo sapiens Q8TAP4-4
Validated Y2H
32296183
Intra LDB2 O43679 EGLN3 Homo sapiens Q9H6Z9
Validated Y2H
32296183
Intra LDB2 O43679 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra LDB2 O43679 HDAC7 Homo sapiens Q8WUI4-6
Validated Y2H
32296183
Intra LDB2 O43679 TSNAX Homo sapiens Q99598
Validated Y2H
32296183
Intra LDB2 O43679 TSNAX Homo sapiens Q99598
Y2H
18330356
Intra LDB2 O43679 LMO4 Homo sapiens P61968
Y2H
15231748
Intra LDB2 O43679 LMO4 Homo sapiens P61968
Y2H
18330356
Intra LDB2 O43679 LMO4 Homo sapiens P61968
Validated Y2H
32296183
Intra LDB2 O43679 EXOC3L1 Homo sapiens Q86VI1
Validated Y2H
32296183
Intra LDB2 O43679 SSBP3 Homo sapiens Q9BWW4
Y2H
18330356
Intra LDB2 O43679 SSBP3 Homo sapiens Q9BWW4
Y2H Array
20211142
Intra LDB2 O43679 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra LDB2 O43679 PSMB1 Homo sapiens P20618
Validated Y2H
32296183
Intra LDB2 O43679 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
32296183
Intra LDB2 O43679 MYDGF Homo sapiens Q969H8
Validated Y2H
32296183
Intra LDB2 O43679 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra LDB2 O43679 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra LDB2 O43679 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra LDB2 O43679 DGCR6L Homo sapiens Q9BY27
Validated Y2H
32296183
Intra LDB2 O43679 LHX8 Homo sapiens Q68G74
Validated Y2H
32296183
Intra LDB2 O43679 LMO1 Homo sapiens P25800
Validated Y2H
32296183
Intra LDB2 O43679 TTC19 Homo sapiens Q6DKK2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinal Detachment

Retinal Detachments

Rhegmatogenous Retinal Detachment

Ruptured Retina With Detachment

Retinal Hole With Detachment
Acute Erythroid Leukemia

Acute Erythroleukemia

Di Guglielmo'S Syndrome

Aml M6

Acute Myeloid Leukemia Fab-M6

Acute Myeloid Leukemia M6

Erythroleukemia

Aml-M6

Acute Erythroleukemia M6a Subtype

Acute Erythroleukemia M6b Subtype

Di Guglielmo Syndrome

Acute Myeloid Leukemia, M6 Type

Acute Erythroblastic Leukemia

Acute Erythroleukemia - M6a Subtype

Acute Erythroleukemia - M6b Subtype

Acute Erythraemia And Erythroleukaemia

Acute Erythroid Leukaemia Without Mention Of Remission

Erythraemia

Erythraemic Myelosis

Erythroleukaemia

Acute Erythraemic Myelosis

Acute Erythraemia
Fetal Hemoglobin Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin

Delta-Beta-Thalassemia

Delta-Beta Thalassemia

Delta Beta-Thalassemia

HBFQTL1

Hemoglobin F, Hereditary Persistence Of

Hpfh

Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related

Hemoglobin, Fetal, Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin Thalassemia

Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]

Fetal Haemoglobin

Persistence Of Fetal Haemoglobin

Persistent Haemoglobin F
Hemoglobinopathy

Hemoglobinopathies
Sickle Cell Anemia

Hemoglobin Sc Disease

Anemia, Sickle Cell

Hbsc Disease

Sickle Cell-Hemoglobin C Disease Syndrome

Hb Ss Disease

Sickle Cell Trait

Drepanocytosis

Haemoglobin Sc Disease

Hb Sc Disease

Hb-S/Hb-C Disease

Hb-Ss Disease Without Crisis

Hemoglobin S Disease Without Crisis

Sickle Cell Anaemia

Sickle-Cell/Hb-C Disease Without Crisis

Sickle Cell - Hemoglobin C Disease

Hbs Disease

Hemoglobin S Disease

Sickling Disorder Due To Hemoglobin S

SKCA

Sickle Cell Disease

Sickle Cell-Hemoglobin C Disease

Sickle-Cell Disease Carrier

Sickle-Cell Heterozygous Disorder

Haemoglobin A-S Genotype

Hb-S - [Sickle Cell Haemoglobin] Carrier

Sickle Cell Haemoglobin Trait

As - [Sickle Cell Trait]

Hbas - [Sickle Cell Haemoglobin Trait]

Sickle-Cell Trait Haemoglobin Disease

Haemoglobin Sickle Cell Trait Disorder

Heterozygous Sickle Cell Trait

Hbas - [Heterozygous Haemoglobin S]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07569 LDB2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LDB2 MGD MGI:894670
Bos taurus LDB2 VGNC VGNC:30822
Rattus norvegicus LDB2 RGD RGD:1307921
Macaca mulatta LDB2 VGNC VGNC:74246
Canis familiaris LDB2 VGNC VGNC:42619
Felis catus LDB2 VGNC VGNC:68028