TSNAX - translin associated factor X Gene

Homo sapiens

Also known as C3PO; TRAX

Gene ID: 7257 | Gene type: protein coding

About TSNAX

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:231,528,669-231,566,524 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 19.1), thyroid (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]

TSNAX Products(1)

mRNA	Protein	Name
NM_005999.3	NP_005990.1	translin-associated protein X

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in siRNA processing	IDA IDA: Inferred from direct assay	21552258	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of endoribonuclease complex	IPI IPI: Inferred from physical interaction	21552258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSNAX Protein Structure

Translin

0
100
200
290 a.a.

Protein Preferred Names

Protein Names

translin-associated protein X

translin-like protein

TSNAX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSNAX	Q99598	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	TSNAX	Q99598	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	TSNAX	Q99598	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	TSNAX	Q99598	TSN	Homo sapiens	Q15631	Y2H Prey Pooling	32296183
Intra	TSNAX	Q99598	TSN	Homo sapiens	Q15631	Experimental Interac	15919079
Intra	TSNAX	Q99598	TSN	Homo sapiens	Q15631	Anti Tag CoIP	33961781
Intra	TSNAX	Q99598	TSN	Homo sapiens	Q15631	Anti Tag CoIP	28514442
Intra	TSNAX	Q99598	TSN	Homo sapiens	Q15631	Y2H Array	32296183
Intra	TSNAX	Q99598	TSN	Homo sapiens	Q15631	Anti Tag CoIP	26496610
Intra	TSNAX	Q99598	AIMP1	Homo sapiens	Q12904	Y2H Prey Pooling	25416956
Intra	TSNAX	Q99598	AIMP1	Homo sapiens	Q12904	Y2H Array	25416956
Intra	TSNAX	Q99598	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	TSNAX	Q99598	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	TSNAX	Q99598	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	TSNAX	Q99598	CEP68	Homo sapiens	Q76N32-2	Y2H Array	32296183
Intra	TSNAX	Q99598	CEP68	Homo sapiens	Q76N32-2	Y2H Prey Pooling	32296183
Intra	TSNAX	Q99598	GPATCH2	Homo sapiens	Q9NW75-2	Validated Y2H	32296183
Intra	TSNAX	Q99598	GPATCH2	Homo sapiens	Q9NW75-2	Y2H Array	32296183
Intra	TSNAX	Q99598	GPATCH2	Homo sapiens	Q9NW75-2	Y2H Prey Pooling	32296183
Intra	TSNAX	Q99598	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
Intra	TSNAX	Q99598	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
Intra	TSNAX	Q99598	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
Intra	TSNAX	Q99598	KLC3	Homo sapiens	Q6P597	Y2H Prey Pooling	25416956
Intra	TSNAX	Q99598	KLC3	Homo sapiens	Q6P597	Y2H Array	25416956
Intra	TSNAX	Q99598	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	TSNAX	Q99598	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	TSNAX	Q99598	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	TSNAX	Q99598	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	TSNAX	Q99598	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	TSNAX	Q99598	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	TSNAX	Q99598	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	TSNAX	Q99598	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	TSNAX	Q99598	LDB2	Homo sapiens	O43679	Y2H Prey Pooling	32296183
Intra	TSNAX	Q99598	LDB2	Homo sapiens	O43679	Y2H Array	32296183
Intra	TSNAX	Q99598	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	TSNAX	Q99598	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	TSNAX	Q99598	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	TSNAX	Q99598	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	TSNAX	Q99598	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	TSNAX	Q99598	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	TSNAX	Q99598	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	TSNAX	Q99598	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	TSNAX	Q99598	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	TSNAX	Q99598	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	TSNAX	Q99598	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	TSNAX	Q99598	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	TSNAX	Q99598	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	TSNAX	Q99598	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	TSNAX	Q99598	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	TSNAX	Q99598	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	TSNAX	Q99598	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	TSNAX	Q99598	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	TSNAX	Q99598	GADD45G	Homo sapiens	O95257	Y2H Pooling	16189514
Intra	TSNAX	Q99598	BLOC1S5	Homo sapiens	Q8TDH9	Y2H Array	25416956
Intra	TSNAX	Q99598	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	TSNAX	Q99598	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	TSNAX	Q99598	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	TSNAX	Q99598	TCF12	Homo sapiens	Q99081	Validated Y2H	25416956
Intra	TSNAX	Q99598	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	TSNAX	Q99598	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
Intra	TSNAX	Q99598	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	TSNAX	Q99598	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	TSNAX	Q99598	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	TSNAX	Q99598	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	TSNAX	Q99598	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	TSNAX	Q99598	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	TSNAX	Q99598	SYT17	Homo sapiens	Q9BSW7	Validated Y2H	32296183
Intra	TSNAX	Q99598	CARD9	Homo sapiens	Q9H257	Y2H Array	25416956
Intra	TSNAX	Q99598	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	TSNAX	Q99598	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	TSNAX	Q99598	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	TSNAX	Q99598	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	TSNAX	Q99598	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TSNAX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82512	Translin Associated Protein X Antibody (YA2257)	WB	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group U

Fanconi Anemia Complementation Group U

FANCU

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15156	TSNAX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSNAX	RGD	RGD:621574
Felis catus	TSNAX	VGNC	VGNC:103757
Canis familiaris	TSNAX	VGNC	VGNC:103053
Macaca mulatta	TSNAX	VGNC	VGNC:100178
Mus musculus	TSNAX	MGD	MGI:1855672

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