EIF1AY - eukaryotic translation initiation factor 1A Y-linked Gene

Homo sapiens

Also known as eIF-4C

Gene ID: 9086 | Gene type: protein coding

About EIF1AY

Cytogenetic location: Yq11.223 Genomic coordinates (GRCh38): Y:20,575,776-20,593,154 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 13.9), prostate (RPKM 13.1) and 20 other tissues.

Summary

This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

EIF1AY Products(2)

mRNA	Protein	Name
NM_001278612.2	NP_001265541.1	eukaryotic translation initiation factor 1A, Y-chromosomal isoform 2
NM_004681.4	NP_004672.2	eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF1AY Protein Structure

eIF-1a

0
100
144 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 1A, Y-chromosomal

eukaryotic translation initiation factor 1A, Y chromosome

EIF1AY Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF1AY	O14602	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	EIF1AY	O14602	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	EIF1AY	O14602	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	EIF1AY	O14602	EIF5B	Homo sapiens	O60841	NMR	12569173
Intra	EIF1AY	O14602	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	EIF1AY	O14602	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	EIF1AY	O14602	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	EIF1AY	O14602	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS04239	EIF1AY Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF1AY	RGD	RGD:1306331
Mus musculus	EIF1AY	MGD	MGI:1913485

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