2. Gene
  3. EIF5B - eukaryotic translation initiation factor 5B Gene

EIF5B - eukaryotic translation initiation factor 5B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IF2

Gene ID: 9669 | Gene type: protein coding

About EIF5B

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:99,337,389-99,401,326 (from NCBI)

This gene has 5 transcripts (splice variants), 108 orthologues and 18 paralogues. Ubiquitous expression in heart (RPKM 26.2), testis (RPKM 23.3) and 25 other tissues.

Summary

Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with Other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

EIF5B Products(1)

mRNA Protein Name
NM_015904.4 NP_056988.3 eukaryotic translation initiation factor 5B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTP binding IDA
IDA: Inferred from direct assay
10659855 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
10659855 GOA
enables GTPase activity IMP
IMP: Inferred from mutant phenotype
35732735 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12569173 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
35732735 GOA
enables translation initiation factor activity IDA
IDA: Inferred from direct assay
10432305 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of translational initiation IDA
IDA: Inferred from direct assay
10432305 GOA
involved in ribosome assembly IDA
IDA: Inferred from direct assay
10659855 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5B Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (632 - 842)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (870 - 944)

IF-2

IF-2: Translation-initiation factor 2 (965 - 1070)

GTP_EFTU_D4

GTP_EFTU_D4: Elongation factor Tu domain 4 (1091 - 1162)

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  • 1220 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 5B

eIF-5B

EIF5B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
EIF5B O60841 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
EIF5B O60841 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
EIF5B O60841 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
EIF5B O60841 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra
EIF5B O60841 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra
EIF5B O60841 GRN Homo sapiens P28799
Y2H Array
32814053
Intra
EIF5B O60841 ETS1 Homo sapiens P14921
TAP
20195357
Intra
EIF5B O60841 ETS1 Homo sapiens P14921
Display Tech
20195357
Intra
EIF5B O60841 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
EIF5B O60841 PEX1 Homo sapiens O43933
Y2H Array
32814053
Intra
EIF5B O60841 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inflammatory Liposarcoma
Acquired Color Blindness

Acquired Color Vision Deficiencies

Acquired Color Vision Deficiency

Acquired Colour Blindness

Acquired Colour Vision Deficiencies

Acquired Colour Vision Deficiency
Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2
Primary Polycythemia

Familial Erythrocytosis

Familiar Polycythemia

Benign Familial Polycythemia

Congenital Erythrocytosis

Familial Polycythemia

Hereditary Erythrocytosis

Primary Familial Polycythemia

Erythrocytosis, Familial

Polycythemia Vera

Primary Familial Polycythaemia

Primary Inherited Polycythaemia
Parameningeal Embryonal Rhabdomyosarcoma
Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04288 EIF5B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EIF5B VGNC VGNC:28420
Mus musculus EIF5B MGD MGI:2441772
Felis catus EIF5B VGNC VGNC:61799
Rattus norvegicus EIF5B RGD RGD:735017
Macaca mulatta EIF5B VGNC VGNC:72148
Canis familiaris EIF5B VGNC VGNC:40294