1. Gene
  2. IL33 - interleukin 33 Gene

IL33 - interleukin 33 Gene

Homo sapiens

Also known as DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26

Gene ID: 90865 | Gene type: protein coding

About IL33

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:6,215,149-6,257,983 (from NCBI)

This gene has 6 transcripts (splice variants) and 89 orthologues. Ubiquitous expression in urinary bladder (RPKM 34.7), lung (RPKM 27.3) and 23 other tissues.

Summary

The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

IL33 Products(9)

mRNA Protein Name
NM_001199640.2 NP_001186569.1 interleukin-33 isoform b
NM_001199641.2 NP_001186570.1 interleukin-33 isoform c
NM_001314044.2 NP_001300973.1 interleukin-33 isoform a precursor
NM_001314045.2 NP_001300974.1 interleukin-33 isoform a precursor
NM_001314046.2 NP_001300975.1 interleukin-33 isoform d
NM_001314047.2 NP_001300976.1 interleukin-33 isoform d
NM_001314048.2 NP_001300977.1 interleukin-33 isoform e
NM_001353802.2 NP_001340731.1 interleukin-33 isoform f
NM_033439.4 NP_254274.1 interleukin-33 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytokine activity IDA
IDA: Inferred from direct assay
19841166 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16286016 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of inflammatory response to wounding IDA
IDA: Inferred from direct assay
27830702 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17185418 GOA
involved in positive regulation of chemokine production IDA
IDA: Inferred from direct assay
19841166 GOA
involved in positive regulation of macrophage activation IDA
IDA: Inferred from direct assay
19841166 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22215666 GOA
is active in extracellular space IDA
IDA: Inferred from direct assay
27830702 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18787100 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL33 Protein Structure

IL33

IL33: Interleukin 33 (5 - 268)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

interleukin-33

DVS27-related protein

IL33 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IL33 O95760 H2AC11 Homo sapiens P0C0S8
Pull Down
18688256
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL33 Proteins

Cat. No. Product Name Accession Purity
HY-P7041 IL-33 Protein, Human O95760-1 (S112-T270) ≥95%
HY-P70475 IL-33 Protein, Human (His) O95760-1 (S112-T270) ≥95%
HY-P70475AF Animal-Free IL-33 Protein, Human (His) O95760-1 (S112-T270) ≥95%

Related Diseases

Diseases Alias
Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip

Granulomatous Mastitis

Idiopathic Granulomatous Mastitis

Loeffler Syndrome

Loeffler'S Pneumonia

Loffler'S Syndrome

Simple Pulmonary Eosinophilia

Esophagitis

Acute Esophagitis

Respiratory Allergy

Airway Allergy

Chronic Asthma
Conjunctivitis

Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva

Ophthalmia

Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis

Schistosomiasis

Katayama Fever

Bilharzia

Bilharziasis

Schistosomiasis Mansoni

Blood Fluke

Schistosoma Mansoni Infection

Snail Fever

Acute Schistosomiasis

Schistosomiasis Manson

Schistosomiasis Due To Schistosoma Mansoni [Intestinal Schistosomiasis]

Intestinal Schistosomiasis Nos

Intestinal Schistosomiasis

Egyptian Splenomegaly

Bilharziasis Of Intestine

Schistosomal Dysentery

Schistosomiasis Of Colon

Asiatic Schistosomiasis

Eastern Schistosomiasis

Schistosoma Japonicum Infection

Schistosomiasis Japonicum

Katayama Disease

Katayama Syndrome

Oriental Schistosomiasis

Nasal Cavity Disease

Disorder Of Nasal Cavity

Rhinitis

Runny Nose

T2-Low Asthma

Type 2 Low Endotype

Rosacea

Erythematotelangiectatic Rosacea

Papulopustular Rosacea

Phymatous Rosacea

Acne Roscea

Acne, Erythematosa

Granulomatous Rosacea

Ocular Rosacea

Acne Rosacea

Hypertrophic Rosacea

T2-High Asthma

Type 2 High Endotype

Nose Disease

Nose Diseases

Disorder Of The Nose

Nasal Disorder

Abnormality Of The Nose

Bronchiolitis
Parasitic Helminthiasis Infectious Disease

Helminthiasis

Intestinal Helminthiasis

Helminth Infection

Helminthosis

Worm Infection

Worm Infections

Helminth Infections

Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

Parasitic Enteritis

Metazoal Dysentery

Intestinal Worms Nos

Acute Asthma
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos

Bronchial Disease

Bronchial Diseases

Bronchial Disorders

Bronchial Spasm

Intrinsic Asthma

Non-Atopic Asthma

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Occupational Asthma
Environmental Induced Asthma

Irritant Asthma

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Achalasia

Cardiospasm

Achalasia Of Cardia

Esophageal Achalasia

Hypertensive Lower Esophageal Sphincter

Idiopathic Achalasia

Achalasia Cardia

Idiopathic Achalasia Of Esophagus

Primary Achalasia

Achalasia Of Esophagus

Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

Aperistalsis Of The Oesophagus

Achalasia Of Oesophagus

Oesophageal Achalasia

Achalasia Nos

Cardia Spasm

Cardia Achalasia

Oesophageal Cardiospasm

Oesophagus Achalasia

Reflex Cardiospasm

Legume Allergy

Fabaceae Allergy

Fruit Allergy

Allergy To Fruit

Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute

Rhino-Sinusitis

Rhinosinusitis

Common Colds

Acute Infective Rhinitis

Cold

Coryza

Head Cold

Infective Nasopharyngitis

Rhinopharyngitis

Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos

Epipharyngitis

Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation

Mastitis

Breast Inflammation

Inflammatory Breast Disease

Inflammatory Disease Of Breast

Inflammation Of Non-Human Mammary Gland

Inflammatory Disorder Of Breast

Mastitis Nos

Acute Mastitis Nos

Acute Nonpuerperal Mastitis

Nonpuerperal Mastitis Nos

Subacute Mastitis Nos

Chronic Conjunctivitis
Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact

Chronic Ethmoiditis

Chronic Ethmoidal Sinusitis

Chronic Ethmoid Sinusitis

Ethmoidal Sinusitis - Chronic

Peanut Allergy

Allergy To Peanuts

Peanut Allergic Reaction

Allergies Peanut

Peanut Hypersensitivity

Allergic Conjunctivitis

Conjunctivitis Allergic

Conjunctivitis, Allergic

Allergen-Induced Conjunctivitis

Seasonal Allergic Conjunctivitis

Perennial Allergic Conjunctivitis

Spring Conjunctivitis

Acute Allergic Conjunctivitis

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Near-Fatal Asthma
Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Chronic Rhinitis

Rhinitis - Chronic

Chronic Rhinitis Nos

Rhinitis

Rhinitis Nos

Thunderstorm Triggered Asthma

Thunderstorm Asthma

Thunderstorm Related Asthma

Thiopental Allergy

Penthiobarbital Allergy

Pentothiobarbital Allergy

Goat Milk Allergy

Capra Hircus Milk Allergy

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis

EOE1

Esophagitis, Eosinophilic

Ee

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Pneumothorax, Primary Spontaneous

Primary Spontaneous Pneumothorax

Spontaneous Pneumothorax

Familial Spontaneous Pneumothorax

PSP

Pneumothorax

Intermittent Asthma
Food Allergy

Food Hypersensitivity

Food Allergies

Allergy Food

Food Allergen-Induced Hypersensitivity

Conjunctival Disease

Conjunctival Diseases

Conjunctival Disorder

Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Leukocyte Disease

Leukocyte Disorders

Dermatitis, Atopic, 5

ATOD5

Atopic Dermatitis 5

Dermatitis, Atopic, Susceptibility To, 5

Dermatitis, Atopic 5

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Integumentary System Disease
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Chronic Congestive Splenomegaly
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta IL33 VGNC VGNC:73606
Canis familiaris IL33 VGNC VGNC:41982
Bos taurus IL33 VGNC VGNC:30155
Mus musculus IL33 MGD MGI:1924375
Felis catus IL33 VGNC VGNC:62912
Rattus norvegicus IL33 RGD RGD:1311155
Macaca fascicularis IL33 NCBI NCBI:102140695
Others IL33 NCBI