2. Gene
  3. CNOT9 - CCR4-NOT transcription complex subunit 9 Gene

CNOT9 - CCR4-NOT transcription complex subunit 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RCD1; CAF40; CT129; RCD-1; RQCD1

Gene ID: 9125 | Gene type: protein coding

About CNOT9

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,568,839-218,597,080 (from NCBI)

This gene has 9 transcripts (splice variants) and 241 orthologues. Ubiquitous expression in testis (RPKM 10.4), lymph node (RPKM 9.1) and 25 other tissues.

Summary

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]

CNOT9 Products(3)

mRNA Protein Name
NM_001271634.2 NP_001258563.1 CCR4-NOT transcription complex subunit 9 isoform 1
NM_001271635.2 NP_001258564.1 CCR4-NOT transcription complex subunit 9 isoform 3
NM_005444.3 NP_005435.1 CCR4-NOT transcription complex subunit 9 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
20878056 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
20878056 GOA
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
18180299 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18180299 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
24768540 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
24768540 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16778766 GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20878056 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
20878056 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
19558367 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20878056 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT9 Protein Structure

Rcd1

Rcd1: Cell differentiation family, Rcd1-like (24 - 285)

  • 0
  • 100
  • 200
  • 299 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 9

RCD1 required for cell differentiation1 homolog

CNOT9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CNOT9 Q92600 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
17452450
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1
Skin Melanoma

Cutaneous Melanoma

Malignant Ear Melanoma

Malignant Lip Melanoma

Malignant Lower Limb Melanoma

Malignant Melanoma Of Ear And/Or External Auricular Canal

Malignant Melanoma Of Skin Of Lower Limb

Malignant Melanoma Of Skin Of Trunk Except Scrotum

Malignant Melanoma Of Skin Of Upper Limb

Malignant Neck Melanoma

Malignant Scalp Melanoma

Malignant Trunk Melanoma

Malignant Upper Limb Melanoma

Melanoma, Cutaneous Malignant

Melanoma

Malignant Melanoma Of Skin

Melanoma Nos

Malignant Mole, Meaning Melanoma Of Unspecified Site

Melanoma Of Unspecified Site

Cutaneous Malignant Melanoma

Mm - [Malignant Melanoma]
Gastric Adenocarcinoma

Adenocarcinoma Of Stomach

Stomach Adenocarcinoma

Adenocarcinoma Gastric

Intestinal Type Adenocarcinoma Of Unspecified Site

Diffuse Type Adenocarcinoma Of Unspecified Site
Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Bladder

Transitional Cell Carcinoma Of The Bladder

Urinary Bladder Urothelial Carcinoma

Urothelial Bladder Carcinoma

Carcinoma Transitional Cell Bladder

Tcc - [Transitional Cell Carcinoma] Of Bladder
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02909 CNOT9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CNOT9 VGNC VGNC:71165
Canis familiaris CNOT9 VGNC VGNC:39420
Mus musculus CNOT9 MGD MGI:1928902
Rattus norvegicus CNOT9 RGD RGD:1311495
Felis catus CNOT9 VGNC VGNC:80171
Bos taurus CNOT9 VGNC VGNC:27524
Others CNOT9 NCBI