CNOT6L - CCR4-NOT transcription complex subunit 6 like Gene

Homo sapiens

Also known as CCR4b

Gene ID: 246175 | Gene type: protein coding

About CNOT6L

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,713,387-77,820,269 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 8.9) and 25 other tissues.

Summary

Predicted to enable poly(A)-specific ribonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT6L Products(13)

mRNA	Protein	Name
NM_001286790.2	NP_001273719.1	CCR4-NOT transcription complex subunit 6-like isoform 1
NM_001365006.1	NP_001351935.1	CCR4-NOT transcription complex subunit 6-like isoform 2
NM_001365007.2	NP_001351936.1	CCR4-NOT transcription complex subunit 6-like isoform 2
NM_001387835.1	NP_001374764.1	CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387836.1	NP_001374765.1	CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387837.1	NP_001374766.1	CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387838.1	NP_001374767.1	CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387839.1	NP_001374768.1	CCR4-NOT transcription complex subunit 6-like isoform 4
NM_001387840.1	NP_001374769.1	CCR4-NOT transcription complex subunit 6-like isoform 4
NM_001387841.1	NP_001374770.1	CCR4-NOT transcription complex subunit 6-like isoform 5
NM_001387842.1	NP_001374771.1	CCR4-NOT transcription complex subunit 6-like isoform 6
NM_001387843.1	NP_001374772.1	CCR4-NOT transcription complex subunit 6-like isoform 6
NM_144571.3	NP_653172.2	CCR4-NOT transcription complex subunit 6-like isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17452450	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21233283	GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly	IMP IMP: Inferred from mutant phenotype	21233283	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21233283	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21233283	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT6L Protein Structure

LRR_8

Exo_endo_phos

0
100
200
300
400
500
555 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 6-like

carbon catabolite repressor protein 4 homolog B

CNOT6L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNOT6L	Q96LI5	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	33961781
Intra	CNOT6L	Q96LI5	CNOT1	Homo sapiens	A5YKK6	Anti Bait CoIP	21984185
Intra	CNOT6L	Q96LI5	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	22977175
Intra	CNOT6L	Q96LI5	TNKS1BP1	Homo sapiens	Q9C0C2	Anti Tag CoIP	17452450
Intra	CNOT6L	Q96LI5	TNKS1BP1	Homo sapiens	Q9C0C2	Anti Tag CoIP	33961781
Intra	CNOT6L	Q96LI5	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	33961781
Intra	CNOT6L	Q96LI5	CNOT7	Homo sapiens	Q9UIV1	Validated Y2H	32296183
Intra	CNOT6L	Q96LI5	CNOT7	Homo sapiens	Q9UIV1	Y2H Prey Pooling	32296183
Intra	CNOT6L	Q96LI5	CNOT7	Homo sapiens	Q9UIV1	Anti Bait CoIP	21984185
Intra	CNOT6L	Q96LI5	CNOT7	Homo sapiens	Q9UIV1	Y2H Array	32296183
Intra	CNOT6L	Q96LI5	CNOT9	Homo sapiens	Q92600	Anti Tag CoIP	33961781
Intra	CNOT6L	Q96LI5	TOB1	Homo sapiens	P50616	TAP	18377426
Intra	CNOT6L	Q96LI5	TOB1	Homo sapiens	P50616	Anti Tag CoIP	18377426
Intra	CNOT6L	Q96LI5	CNOT8	Homo sapiens	Q9UFF9	Validated Y2H	32296183
Intra	CNOT6L	Q96LI5	CNOT8	Homo sapiens	Q9UFF9	Anti Tag CoIP	33961781
Intra	CNOT6L	Q96LI5	CNOT8	Homo sapiens	Q9UFF9	Y2H Array	32296183
Intra	CNOT6L	Q96LI5	CNOT8	Homo sapiens	Q9UFF9	Y2H Prey Pooling	32296183
Intra	CNOT6L	Q96LI5	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02906	CNOT6L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CNOT6L	VGNC	VGNC:39417
Felis catus	CNOT6L	VGNC	VGNC:61029
Bos taurus	CNOT6L	VGNC	VGNC:27521
Rattus norvegicus	CNOT6L	RGD	RGD:1309128
Mus musculus	CNOT6L	MGD	MGI:2443154
Macaca mulatta	CNOT6L	VGNC	VGNC:100211

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