ISX - intestine specific homeobox Gene

Homo sapiens

Also known as Pix-1; RAXLX

Gene ID: 91464 | Gene type: protein coding

About ISX

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,066,158-35,087,387 (from NCBI)

This gene has 2 transcripts (splice variants), 106 orthologues, 50 paralogues and is associated with 51 phenotypes. Biased expression in duodenum (RPKM 20.1), colon (RPKM 15.2) and 1 other tissue.

Summary

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 Amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]

ISX Products(1)

mRNA	Protein	Name
NM_001303508.2	NP_001290437.1	intestine-specific homeobox

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISX Protein Structure

Homeobox

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

intestine-specific homeobox

RAX-like homeobox

ISX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ISX	Q2M1V0	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	ISX	Q2M1V0	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	ISX	Q2M1V0	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	ISX	Q2M1V0	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	ISX	Q2M1V0	UBAP2	Homo sapiens	Q5T6F2	Validated Y2H	32296183
Intra	ISX	Q2M1V0	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	ISX	Q2M1V0	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	ISX	Q2M1V0	ROR2	Homo sapiens	Q01974	Y2H Array	32296183
Intra	ISX	Q2M1V0	ROR2	Homo sapiens	Q01974	Y2H Prey Pooling	32296183
Intra	ISX	Q2M1V0	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	ISX	Q2M1V0	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypervitaminosis A

Hypervitaminosis A, Susceptibility To

Hyperalimentation Of Vitamin A

Macular Degeneration, Age-Related, 10

ARMD10	Age Related Macular Degeneration 10
Macular Degeneration, Age-Related, Type 10

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12323	ISX-9	Activator	99.19%	Unkown
HY-113790	ISX-1	Inhibitor	98.36%	Unkown
HY-148694	ISX-3	Activator	99.68%	Unkown
HY-12323G	ISX-9 (GMP)	Activator	/	Unkown
HY-RS06940	ISX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ISX	VGNC	VGNC:42115
Mus musculus	ISX	MGD	MGI:1918847
Macaca mulatta	ISX	VGNC	VGNC:107796
Bos taurus	ISX	VGNC	VGNC:30305
Felis catus	ISX	VGNC	VGNC:62981
Rattus norvegicus	ISX	RGD	RGD:1592776

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