IDI2 - isopentenyl-diphosphate delta isomerase 2 Gene

Homo sapiens

Also known as IPPI2

Gene ID: 91734 | Gene type: protein coding

About IDI2

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:1,018,910-1,025,859 (from NCBI)

This gene has 1 transcript (splice variant), 149 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 2.6), thyroid (RPKM 1.6) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of Cholesterol and Other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]

IDI2 Products(1)

mRNA	Protein	Name
NM_033261.3	NP_150286.1	isopentenyl-diphosphate delta-isomerase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables isopentenyl-diphosphate delta-isomerase activity	IDA IDA: Inferred from direct assay	17202134	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within isopentenyl diphosphate metabolic process	IDA IDA: Inferred from direct assay	17202134	GOA
involved in isoprenoid biosynthetic process	IDA IDA: Inferred from direct assay	17202134	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisome	IDA IDA: Inferred from direct assay	17202134	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IDI2 Protein Structure

NUDIX

0
100
200
227 a.a.

Protein Preferred Names

Protein Names

isopentenyl-diphosphate delta-isomerase 2

IPP isomerase 2

IDI2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IDI2	Q9BXS1	LDB1	Homo sapiens	Q86U70-2	Y2H Array	32296183
Intra	IDI2	Q9BXS1	LDB1	Homo sapiens	Q86U70-2	Anti Tag CoIP	28514442
Intra	IDI2	Q9BXS1	LDB1	Homo sapiens	Q86U70-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IDI2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70903	IDI2 Protein, Human (His)	Q9BXS1 (M1-V227)	≥95%
HY-P70903A	IDI2 Protein, Human (C-His)	Q9BXS1 (D3-V227)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06537	IDI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IDI2	RGD	RGD:1559783
Mus musculus	IDI2	MGD	MGI:2444315
Others	IDI2	NCBI

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