NXPE3 - neurexophilin and PC-esterase domain family member 3 Gene

Homo sapiens

Also known as FAM55C; MST115; MSTP115

Gene ID: 91775 | Gene type: protein coding

About NXPE3

This gene has 33 transcripts (splice variants), 504 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 6.4), lymph node (RPKM 5.0) and 24 other tissues.

Summary

This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

NXPE3 Products(11)

mRNA	Protein	Name
NM_001134456.2	NP_001127928.1	NXPE family member 3 isoform 1 precursor
NM_001348990.2	NP_001335919.1	NXPE family member 3 isoform 1 precursor
NM_001348991.2	NP_001335920.1	NXPE family member 3 isoform 1 precursor
NM_001348992.2	NP_001335921.1	NXPE family member 3 isoform 1 precursor
NM_001348993.2	NP_001335922.1	NXPE family member 3 isoform 1 precursor
NM_001348994.2	NP_001335923.1	NXPE family member 3 isoform 1 precursor
NM_001348995.2	NP_001335924.1	NXPE family member 3 isoform 1 precursor
NM_001348996.2	NP_001335925.1	NXPE family member 3 isoform 2
NM_001348997.2	NP_001335926.1	NXPE family member 3 isoform 2
NM_001348998.2	NP_001335927.1	NXPE family member 3 isoform 2
NM_145037.4	NP_659474.1	NXPE family member 3 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NXPE3 Protein Structure

Neurexophilin

0
100
200
300
400
500
559 a.a.

Protein Preferred Names

Protein Names

NXPE family member 3

family with sequence similarity 55, member C

NXPE3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NXPE3	Q969Y0	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	NXPE3	Q969Y0	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	NXPE3	Q969Y0	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	NXPE3	Q969Y0	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	NXPE3	Q969Y0	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	NXPE3	Q969Y0	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	NXPE3	Q969Y0	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	NXPE3	Q969Y0	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	NXPE3	Q969Y0	OS9	Homo sapiens	Q13438	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09716	NXPE3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NXPE3	VGNC	VGNC:32380
Mus musculus	NXPE3	MGD	MGI:2686598
Rattus norvegicus	NXPE3	RGD	RGD:1584648
Macaca mulatta	NXPE3	VGNC	VGNC:75476
Felis catus	NXPE3	VGNC	VGNC:63938
Canis familiaris	NXPE3	VGNC	VGNC:44075

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