CHMP7 - charged multivesicular body protein 7 Gene

Homo sapiens

Gene ID: 91782 | Gene type: protein coding

About CHMP7

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,243,637-23,261,999 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 21.0), appendix (RPKM 14.0) and 25 other tissues.

Summary

Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]

CHMP7 Products(3)

mRNA	Protein	Name
NM_001317899.2	NP_001304828.1	charged multivesicular body protein 7 isoform 2
NM_001363183.2	NP_001350112.1	charged multivesicular body protein 7 isoform 3
NM_152272.5	NP_689485.1	charged multivesicular body protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16856878	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in exit from mitosis	IMP IMP: Inferred from mutant phenotype	26040712	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in late endosome to vacuole transport	IMP IMP: Inferred from mutant phenotype	16856878	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	16554368	GOA
involved in nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	26040712	GOA
involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in plasma membrane repair	IDA IDA: Inferred from direct assay	24482116	GOA
involved in protein localization to chromatin	IMP IMP: Inferred from mutant phenotype	28242692	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	17984323	GOA
involved in viral budding from plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA
involved in viral budding via host ESCRT complex	IDA IDA: Inferred from direct assay	24878737	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESCRT III complex	IDA IDA: Inferred from direct assay	16856878	GOA
located in amphisome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in chromatin	IDA IDA: Inferred from direct assay	28242692	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	26040712	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	26040712	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in midbody	IDA IDA: Inferred from direct assay	26040712	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	16554368	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	26040712	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	26040713	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP7 Protein Structure

Snf7

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

charged multivesicular body protein 7

CHMP family, member 7

CHMP7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CHMP7	Q8WUX9	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	CHMP7	Q8WUX9	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	CHMP7	Q8WUX9	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	CHMP7	Q8WUX9	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	CHMP7	Q8WUX9	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	CHMP7	Q8WUX9	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	CHMP7	Q8WUX9	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	CHMP7	Q8WUX9	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	CHMP7	Q8WUX9	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	CHMP7	Q8WUX9	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	CHMP7	Q8WUX9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	CHMP7	Q8WUX9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	CHMP7	Q8WUX9	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	CHMP7	Q8WUX9	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	CHMP7	Q8WUX9	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	CHMP7	Q8WUX9	CHMP4B	Homo sapiens	Q9H444	Y2H	16856878
Intra	CHMP7	Q8WUX9	CHMP4B	Homo sapiens	Q9H444	Pull Down	16856878

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02648	CHMP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CHMP7	VGNC	VGNC:60866
Rattus norvegicus	CHMP7	RGD	RGD:1308779
Bos taurus	CHMP7	VGNC	VGNC:27306
Mus musculus	CHMP7	MGD	MGI:1913922
Canis familiaris	CHMP7	VGNC	VGNC:54933
Macaca mulatta	CHMP7	VGNC	VGNC:71122

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