ZMYM4 - zinc finger MYM-type containing 4 Gene

Homo sapiens

Also known as MYM; CDIR; ZNF262; ZNF198L3

Gene ID: 9202 | Gene type: protein coding

About ZMYM4

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,268,709-35,422,058 (from NCBI)

This gene has 6 transcripts (splice variants), 132 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 15.0), ovary (RPKM 10.1) and 25 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in Cytoskeleton organization and regulation of cell morphogenesis. [provided by Alliance of Genome Resources, Apr 2022]

ZMYM4 Products(5)

mRNA	Protein	Name
NM_001350138.2	NP_001337067.1	zinc finger MYM-type protein 4 isoform 2
NM_001350139.2	NP_001337068.1	zinc finger MYM-type protein 4 isoform 3
NM_001350140.2	NP_001337069.1	zinc finger MYM-type protein 4 isoform 3
NM_001375653.1	NP_001362582.1	zinc finger MYM-type protein 4 isoform 4
NM_005095.3	NP_005086.2	zinc finger MYM-type protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	21834987	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYM4 Protein Structure

zf-FCS

DUF3504

0
300
600
900
1200
1548 a.a.

Protein Preferred Names

Protein Names

zinc finger MYM-type protein 4

cell death inhibiting RNA

ZMYM4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZMYM4	Q5VZL5	ROR2	Homo sapiens	A1L4F5	Validated Y2H	25416956
Intra	ZMYM4	Q5VZL5	ROR2	Homo sapiens	A1L4F5	Y2H Prey Pooling	25416956
Intra	ZMYM4	Q5VZL5	ROR2	Homo sapiens	A1L4F5	Y2H Array	25416956
Intra	ZMYM4	Q5VZL5	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	ZMYM4	Q5VZL5	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	ZMYM4	Q5VZL5	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	ZMYM4	Q5VZL5	FHL2	Homo sapiens	Q14192	Y2H Array	25416956
Intra	ZMYM4	Q5VZL5	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	25416956
Intra	ZMYM4	Q5VZL5	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	25416956
Intra	ZMYM4	Q5VZL5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	ZMYM4	Q5VZL5	CTCF	Homo sapiens	P49711	Y2H Prey Pooling	25416956
Intra	ZMYM4	Q5VZL5	CTCF	Homo sapiens	P49711	Validated Y2H	25416956
Intra	ZMYM4	Q5VZL5	CTCF	Homo sapiens	P49711	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Parkinson Disease 20, Early-Onset

Early-Onset Parkinson Disease 20	PARK20
Parkinson'S Disease 20	Early-Onset Parkinson'S Disease 20
Parkinson Disease, Type 20, Early-Onset

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16091	ZMYM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZMYM4	MGD	MGI:1915035
Felis catus	ZMYM4	VGNC	VGNC:67260
Macaca mulatta	ZMYM4	VGNC	VGNC:78887
Rattus norvegicus	ZMYM4	RGD	RGD:1309545
Bos taurus	ZMYM4	VGNC	VGNC:37200
Canis familiaris	ZMYM4	VGNC	VGNC:48648

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