ZMYM3 - zinc finger MYM-type containing 3 Gene

Homo sapiens

Also known as MYM; XFIM; ZNF261; DXS6673E; ZNF198L2

Gene ID: 9203 | Gene type: protein coding

About ZMYM3

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,239,624-71,255,290 (from NCBI)

This gene has 9 transcripts (splice variants), 142 orthologues, 18 paralogues and is associated with 82 phenotypes. Ubiquitous expression in ovary (RPKM 15.3), testis (RPKM 11.9) and 25 other tissues.

Summary

This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked cognitive disability. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010]

ZMYM3 Products(4)

mRNA	Protein	Name
NM_001171162.1	NP_001164633.1	zinc finger MYM-type protein 3 isoform 2
NM_001171163.1	NP_001164634.1	zinc finger MYM-type protein 3 isoform 3
NM_005096.3	NP_005087.1	zinc finger MYM-type protein 3 isoform 1
NM_201599.3	NP_963893.1	zinc finger MYM-type protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30021884	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	21834987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IMP IMP: Inferred from mutant phenotype	36586412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYM3 Protein Structure

zf-FCS

DUF3504

0
300
600
900
1200
1370 a.a.

Protein Preferred Names

Protein Names

zinc finger MYM-type protein 3

zinc finger protein 261

ZMYM3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZMYM3	Q14202	H2BC21	Homo sapiens	Q16778	Crosslink	30021884
Intra	ZMYM3	Q14202	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	ZMYM3	Q14202	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	ZMYM3	Q14202	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	ZMYM3	Q14202	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	ZMYM3	Q14202	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	ZMYM3	Q14202	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	ZMYM3	Q14202	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	ZMYM3	Q14202	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	ZMYM3	Q14202	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nasal Cavity Adenocarcinoma

Adenocarcinoma Of Nasal Cavity

Adenocarcinoma Of The Nasal Cavity

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16090	ZMYM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZMYM3	VGNC	VGNC:78886
Bos taurus	ZMYM3	VGNC	VGNC:37199
Mus musculus	ZMYM3	MGD	MGI:1927231
Rattus norvegicus	ZMYM3	RGD	RGD:1564967
Canis familiaris	ZMYM3	VGNC	VGNC:48647
Felis catus	ZMYM3	VGNC	VGNC:67259

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