LRRFIP1 - LRR binding FLII interacting protein 1 Gene

Homo sapiens

Also known as GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1

Gene ID: 9208 | Gene type: protein coding

About LRRFIP1

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,627,587-237,781,643 (from NCBI)

This gene has 17 transcripts (splice variants), 293 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 14.3), bone marrow (RPKM 12.6) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRFIP1 Products(5)

mRNA	Protein	Name
NM_001137550.2	NP_001131022.1	leucine-rich repeat flightless-interacting protein 1 isoform 1
NM_001137551.2	NP_001131023.1	leucine-rich repeat flightless-interacting protein 1 isoform 2
NM_001137552.2	NP_001131024.1	leucine-rich repeat flightless-interacting protein 1 isoform 3
NM_001137553.2	NP_001131025.1	leucine-rich repeat flightless-interacting protein 1 isoform 5
NM_004735.4	NP_004726.2	leucine-rich repeat flightless-interacting protein 1 isoform 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	23099021	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14522076	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14522076	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9671805	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	23099021	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14522076	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRFIP1 Protein Structure

LRRFIP

0
200
400
600
808 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat flightless-interacting protein 1

GC-binding factor 2

Related Diseases

Diseases

Alias

Marasmus

Nutritional Marasmus

Nutritional Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	Unkown
HY-RS07830	LRRFIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LRRFIP1	VGNC	VGNC:59085
Macaca mulatta	LRRFIP1	VGNC	VGNC:99376
Mus musculus	LRRFIP1	MGD	MGI:1342770
Rattus norvegicus	LRRFIP1	RGD	RGD:1359548
Bos taurus	LRRFIP1	VGNC	VGNC:55253
Felis catus	LRRFIP1	VGNC	VGNC:107576
Others	LRRFIP1	NCBI

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