2. Gene
  3. IL32 - interleukin 32 Gene

IL32 - interleukin 32 Gene

  • Gene
  • Protein
  • Disease
  • Agent
Homo sapiens

Also known as NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma

Gene ID: 9235 | Gene type: protein coding

About IL32

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,065,403-3,069,530 (from NCBI)

This gene has 35 transcripts (splice variants) and 8 orthologues. Broad expression in small intestine (RPKM 122.1), spleen (RPKM 121.0) and 22 other tissues.

Summary

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

IL32 Products(19)

mRNA Protein Name
NM_001012631.4 NP_001012649.1 interleukin-32 isoform B
NM_001012632.3 NP_001012650.1 interleukin-32 isoform B
NM_001012633.4 NP_001012651.1 interleukin-32 isoform A
NM_001012634.4 NP_001012652.1 interleukin-32 isoform C
NM_001012635.4 NP_001012653.1 interleukin-32 isoform C
NM_001012636.2 NP_001012654.1 interleukin-32 isoform D
NM_001012718.4 NP_001012736.1 interleukin-32 isoform B
NM_001308078.4 NP_001295007.1 interleukin-32 isoform E precursor
NM_001369587.3 NP_001356516.1 interleukin-32 isoform E precursor
NM_001369588.3 NP_001356517.1 interleukin-32 isoform E precursor
NM_001369589.3 NP_001356518.1 interleukin-32 isoform B
NM_001369590.3 NP_001356519.1 interleukin-32 isoform C
NM_001369591.3 NP_001356520.1 interleukin-32 isoform C
NM_001369592.3 NP_001356521.1 interleukin-32 isoform C
NM_001369593.3 NP_001356522.1 interleukin-32 isoform F
NM_001369595.3 NP_001356524.1 interleukin-32 isoform G
NM_001369596.3 NP_001356525.1 interleukin-32 isoform B
NM_001376923.1 NP_001363852.1 interleukin-32 isoform B
NM_004221.7 NP_004212.4 interleukin-32 isoform B
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16488976 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of negative regulation of viral life cycle IDA
IDA: Inferred from direct assay
23729669 GOA
acts upstream of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23729669 GOA
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
23729669 GOA
acts upstream of or within positive regulation of type III interferon production IDA
IDA: Inferred from direct assay
23729669 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL32 Protein Structure

IL32

IL32: Interleukin 32 (114 - 211)

  • 0
  • 100
  • 200
  • 234 a.a.
Protein Preferred Names Protein Names

interleukin-32

interleukin-32 eta

Recombinant IL32 Proteins

Cat. No. Product Name Accession Purity
HY-P73884 IL-32 alpha Protein, Human (HEK293, His) P24001-4/NP_001012651 (M1-K131) ≥95%
HY-P700124AF Animal-Free IL-32 alpha Protein, Human (His) P24001-4 (M1-K131) ≥95%

Related Diseases

Diseases Alias
Microscopic Polyangiitis

Microscopic Polyarteritis

Mpa

Micropolyangiitis
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Granulomatosis With Polyangiitis

GPA

Wegener Granulomatosis

Wegener Granulomatosis, Formerly

Midline Granulomatosis

Wg, Formerly

Necrotizing Respiratory Granulomatosis

Wg

Wegeners Granulomatosis

Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06756 IL32 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown