RPS6KA5 - ribosomal protein S6 kinase A5 Gene

Homo sapiens

Also known as MSK1; RLPK; MSPK1

Gene ID: 9252 | Gene type: protein coding

About RPS6KA5

Cytogenetic location: 14q32.11 Genomic coordinates (GRCh38): 14:90,847,861-91,060,641 (from NCBI)

This gene has 8 transcripts (splice variants), 221 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues.

Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including histone-serine phosphorylation; positive regulation of histone modification; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RPS6KA5 Products(14)

mRNA	Protein	Name
NM_001322227.2	NP_001309156.1	ribosomal protein S6 kinase alpha-5 isoform c
NM_001322228.2	NP_001309157.1	ribosomal protein S6 kinase alpha-5 isoform d
NM_001322229.2	NP_001309158.1	ribosomal protein S6 kinase alpha-5 isoform e
NM_001322230.2	NP_001309159.1	ribosomal protein S6 kinase alpha-5 isoform f
NM_001322231.2	NP_001309160.1	ribosomal protein S6 kinase alpha-5 isoform g
NM_001322232.2	NP_001309161.1	ribosomal protein S6 kinase alpha-5 isoform h
NM_001322233.2	NP_001309162.1	ribosomal protein S6 kinase alpha-5 isoform i
NM_001322234.2	NP_001309163.1	ribosomal protein S6 kinase alpha-5 isoform j
NM_001322235.2	NP_001309164.1	ribosomal protein S6 kinase alpha-5 isoform k
NM_001322236.2	NP_001309165.1	ribosomal protein S6 kinase alpha-5 isoform l
NM_001322237.2	NP_001309166.1	ribosomal protein S6 kinase alpha-5 isoform k
NM_001322238.2	NP_001309167.1	ribosomal protein S6 kinase alpha-5 isoform m
NM_004755.4	NP_004746.2	ribosomal protein S6 kinase alpha-5 isoform a
NM_182398.3	NP_872198.1	ribosomal protein S6 kinase alpha-5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9687510	GOA
enables histone H2AS1 kinase activity	IDA IDA: Inferred from direct assay	15010469	GOA
enables histone H3S10 kinase activity	IMP IMP: Inferred from mutant phenotype	12773393	GOA
enables histone H3S28 kinase activity	IMP IMP: Inferred from mutant phenotype	12773393	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9687510	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9873047	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20018936	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	9687510	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15010469	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12628924	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20018936	GOA
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	15010469	GOA
involved in post-translational protein modification	IMP IMP: Inferred from mutant phenotype	12773393	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9687510	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9687510	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12763138	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18511904	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9687510	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	12628924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KA5 Protein Structure

Pkinase

Pkinase_C

Pkinase

0
200
400
600
802 a.a.

Protein Preferred Names

Protein Names

ribosomal protein S6 kinase alpha-5

90 kDa ribosomal protein S6 kinase 5

RPS6KA5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS6KA5	O75582	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	RPS6KA5	O75582	CSNK2B	Homo sapiens	P67870	Y2H	21988832
Intra	RPS6KA5	O75582	CSNK2B	Homo sapiens	P67870	Pull Down	32707033
Intra	RPS6KA5	O75582	MAP3K20	Homo sapiens	Q9NYL2	Pull Down	21988832
Intra	RPS6KA5	O75582	MAP3K20	Homo sapiens	Q9NYL2	Confocal	21988832
Intra	RPS6KA5	O75582	MAPK14	Homo sapiens	Q16539	Y2H Pooling	20936779

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Joubert Syndrome 28

JBTS28

Coffin-Lowry Syndrome

CLS	Coffin Syndrome 1
Coffin Syndrome	Intellectual Disability With Osteocartilaginous Abnormalities
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Mental Retardation With Osteocartilaginous Abnormalities	Coffin Lowry Syndrome

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12258	RPS6KA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPS6KA5	MGD	MGI:1920336
Bos taurus	RPS6KA5	VGNC	VGNC:34144
Rattus norvegicus	RPS6KA5	RGD	RGD:1308336
Felis catus	RPS6KA5	VGNC	VGNC:64758
Canis familiaris	RPS6KA5	VGNC	VGNC:45742
Macaca mulatta	RPS6KA5	VGNC	VGNC:76931
Others	RPS6KA5	NCBI

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