MAP3K20 - mitogen-activated protein kinase kinase kinase 20 Gene

Homo sapiens

Also known as pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha

Gene ID: 51776 | Gene type: protein coding

About MAP3K20

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:173,075,517-173,268,015 (from NCBI)

This gene has 8 transcripts (splice variants), 147 orthologues, 23 paralogues and is associated with 4 phenotypes. Broad expression in heart (RPKM 51.0), fat (RPKM 33.9) and 21 other tissues.

Summary

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

MAP3K20 Products(2)

mRNA	Protein	Name
NM_016653.3	NP_057737.2	mitogen-activated protein kinase kinase kinase 20 isoform 1
NM_133646.3	NP_598407.1	mitogen-activated protein kinase kinase kinase 20 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11836244	GOA
enables JUN kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11836244	GOA
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11836244	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	11836244	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12761180	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	32610081	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	32289254	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	32289254	GOA
enables small ribosomal subunit rRNA binding	IDA IDA: Inferred from direct assay	32289254	GOA
enables stalled ribosome sensor activity	IDA IDA: Inferred from direct assay	32289254	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	11836244	GOA
acts upstream of GCN2-mediated signaling	IDA IDA: Inferred from direct assay	32610081	GOA
involved in JNK cascade	IDA IDA: Inferred from direct assay	11836244	GOA
involved in MAPK cascade	IDA IDA: Inferred from direct assay	18331592	GOA
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	32289254	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	11836244	GOA
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	26755636	GOA
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	18331592	GOA
involved in limb development	IMP IMP: Inferred from mutant phenotype	26755636	GOA
involved in negative regulation of stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	35857590	GOA
involved in negative regulation of translation in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	32610081	GOA
involved in p38MAPK cascade	IDA IDA: Inferred from direct assay	11836244	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10924358	GOA
involved in positive regulation of mitotic DNA damage checkpoint	IDA IDA: Inferred from direct assay	15342622	GOA
acts upstream of positive regulation of programmed cell death	IDA IDA: Inferred from direct assay	32289254	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12220515	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11836244	GOA
acts upstream of positive effect pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	35857590	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	11836244	GOA
involved in stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	35857590	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	15684425	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K20 Protein Structure

Pkinase_Tyr

SAM_1

0
200
400
600
800 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 20

HCCS-4

MAP3K20 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP3K20	Q9NYL2	RPS6KA5	Homo sapiens	O75582	Y2H	21988832
Intra	MAP3K20	Q9NYL2	RPS6KA5	Homo sapiens	O75582	Anti Tag CoIP	21988832
Intra	MAP3K20	Q9NYL2	ZNF567	Homo sapiens	Q8N184	Y2H	21516116
Intra	MAP3K20	Q9NYL2	ZNF567	Homo sapiens	Q8N184	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Split-Foot Malformation With Mesoaxial Polydactyly

SFMMP	Split-Foot Malformation-Mesoaxial Polydactyly Syndrome
Split-Foot Malformation-Mesoaxial Polydactyly-Nail Abnormalities-Sensorineural Hearing Loss Syndrome

Myopathy, Centronuclear, 6, With Fiber-Type Disproportion

CNM6	Centronuclear Myopathy 6 With Fiber-Type Disproportion
Myopathy, Centronuclear, Type 6, With Fiber-Type Disproportion

Split-Hand/Foot Malformation 1

Ectrodactyly	Split Hand-Foot Malformation 1
SHFM1	Shfd1
Split-Hand Deformity	Split-Hand/Foot Malformation 1 With Or Without Deafness
Split-Hand/Foot Deformity 1	Ecd
Split Hand/Foot Malformation Type 1	Split Hand Foot Deformity 1
Split-Hand/Foot Malformation

Congenital Fiber-Type Disproportion

Congenital Fiber Type Disproportion	Cftdm
Congenital Myopathy With Fiber Type Disproportion	Cftd
Congenital Fiber-Type Disproportion Myopathy	Fiber-Type Disproportion Myopathy, Congenital
Myopathy, Congenital With Fiber-Type Disproportion

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive

Split Hand-Foot Malformation 1 With Sensorineural Hearing Loss	SHFM1D
Deafness, Congenital, With Split Hands And Feet	Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss
Congenital Deafness With Split Hands And Feet	Split Hand-Split Foot-Deafness Syndrome
Split Hand-Split Foot-Hearing Loss Syndrome	Congenital Deafness And Split Hands And Feet
Split-Hand/Foot Malformation, Type 1 With Sensorineural Hearing Loss	Split-Hand-Foot Malformation With Sensorineural Hearing Loss

Centronuclear Myopathy

Myopathy, Centronuclear	Myotubular Myopathy
Cnm	Myopathy, Myotubular
Congenital Structural Myopathy

Myopathy

Muscular Diseases

Myopathies

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-RS08055	MAP3K20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAP3K20	MGD	MGI:2443258
Rattus norvegicus	MAP3K20	RGD	RGD:1561394
Macaca mulatta	MAP3K20	VGNC	VGNC:99379
Canis familiaris	MAP3K20	VGNC	VGNC:53099

Name
Email *

	Sorry, but the email address you supplied was invalid.