ARRDC1 - arrestin domain containing 1 Gene

Homo sapiens

Gene ID: 92714 | Gene type: protein coding

About ARRDC1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,605,686-137,615,360 (from NCBI)

This gene has 12 transcripts (splice variants), 225 orthologues and 5 paralogues. Ubiquitous expression in stomach (RPKM 15.2), spleen (RPKM 13.5) and 25 other tissues.

Summary

Enables several functions, including Arrestin family protein binding activity; ubiquitin ligase-substrate adaptor activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including cellular protein metabolic process; extracellular vesicle biogenesis; and negative regulation of Notch signaling pathway. Located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARRDC1 Products(2)

mRNA	Protein	Name
NM_001317968.2	NP_001304897.1	arrestin domain-containing protein 1 isoform 2
NM_152285.4	NP_689498.1	arrestin domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arrestin family protein binding	IPI IPI: Inferred from physical interaction	23886940	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22315426	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22315426	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22315426	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IMP IMP: Inferred from mutant phenotype	27462458	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in extracellular transport	IMP IMP: Inferred from mutant phenotype	22315426	GOA
involved in extracellular vesicle biogenesis	IMP IMP: Inferred from mutant phenotype	27462458	GOA
involved in negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	23886940	GOA
involved in protein transport	IMP IMP: Inferred from mutant phenotype	27462458	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	27462458	GOA
NOT involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	27462458	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23886940	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	23236378	GOA
NOT located in extracellular exosome	IDA IDA: Inferred from direct assay	22315426	GOA
located in extracellular vesicle	IDA IDA: Inferred from direct assay	22315426	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22315426	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARRDC1 Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
400
433 a.a.

Protein Preferred Names

Protein Names

arrestin domain-containing protein 1

alpha-arrestin 1

ARRDC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARRDC1	Q8N5I2	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	ARRDC1	Q8N5I2	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	ARRDC1	Q8N5I2	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	38270169
Intra	ARRDC1	Q8N5I2	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	33961781
Intra	ARRDC1	Q8N5I2	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	28514442
Intra	ARRDC1	Q8N5I2	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	ARRDC1	Q8N5I2	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	ARRDC1	Q8N5I2	KLHL12	Homo sapiens	Q53G59	Anti Tag CoIP	38270169
Intra	ARRDC1	Q8N5I2	WWP1	Homo sapiens	Q9H0M0	Anti Tag CoIP	38270169
Intra	ARRDC1	Q8N5I2	WWP1	Homo sapiens	Q9H0M0	Validated Y2H	32296183
Intra	ARRDC1	Q8N5I2	WWP1	Homo sapiens	Q9H0M0	Y2H Prey Pooling	32296183
Intra	ARRDC1	Q8N5I2	WWP1	Homo sapiens	Q9H0M0	Y2H Array	32296183
Intra	ARRDC1	Q8N5I2	WWP2	Homo sapiens	O00308	Anti Tag CoIP	38270169
Intra	ARRDC1	Q8N5I2	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	ARRDC1	Q8N5I2	WWP2	Homo sapiens	O00308	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Methemoglobinemia And Ambiguous Genitalia

METAG	Methemoglobinemia Type Iv
Isolated 17,20-Lyase Deficiency, Pure	Methemoglobinemia Due To Deficiency Of Cytochrome B5
Methemoglobinemia Type 4	Methemoglobinemia Type Iv, Formerly
Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly	Pure Isolated 17,20-Lyase Deficiency
Methemoglobinemia, Type Iv

Kleefstra Syndrome 1

9q Subtelomeric Deletion Syndrome	KLEFS1
Chromosome 9q34.3 Deletion Syndrome	9q- Syndrome
9q34 Deletion Syndrome	Kleefstra Syndrome Due To 9q34 Microdeletion
Kleefstra Syndrome	9q-Syndrome
9qstds	Kleefstra Syndrome Due To 9q Subtelomeric Deletion
Kleefstra Syndrome Due To Del(9)(Q34)	Kleefstra Syndrome Due To Monosomy 9q34
Chromosome 9q Subtelomeric Deletion Syndrome	Kleefstra Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01030	ARRDC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARRDC1	VGNC	VGNC:26171
Mus musculus	ARRDC1	MGD	MGI:2446136
Felis catus	ARRDC1	VGNC	VGNC:59943
Canis familiaris	ARRDC1	VGNC	VGNC:38138
Rattus norvegicus	ARRDC1	RGD	RGD:1309961
Macaca mulatta	ARRDC1	VGNC	VGNC:69920

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