WWP1 - WW domain containing E3 ubiquitin protein ligase 1 Gene

Homo sapiens

Also known as AIP5; Tiul1; hSDRP1

Gene ID: 11059 | Gene type: protein coding

About WWP1

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:86,342,547-86,468,503 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 24 paralogues. Ubiquitous expression in liver (RPKM 24.3), gall bladder (RPKM 23.0) and 25 other tissues.

Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

WWP1 Products(1)

mRNA	Protein	Name
NM_007013.4	NP_008944.1	NEDD4-like E3 ubiquitin-protein ligase WWP1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647693	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WWP1 Protein Structure

HECT

0
200
400
600
800
922 a.a.

Protein Preferred Names

Protein Names

NEDD4-like E3 ubiquitin-protein ligase WWP1

HECT-type E3 ubiquitin transferase WWP1

WWP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WWP1	Q9H0M0	ARRDC1	Homo sapiens	Q8N5I2	Anti Tag CoIP	33961781
Intra	WWP1	Q9H0M0	SMAD3	Homo sapiens	P84022	Y2H Prey Pooling	25416956
Intra	WWP1	Q9H0M0	SMAD3	Homo sapiens	P84022	Y2H Array	25416956
Intra	WWP1	Q9H0M0	CPSF6	Homo sapiens	Q16630	Anti Tag CoIP	33961781
Intra	WWP1	Q9H0M0	CPSF6	Homo sapiens	Q16630	Pull Down	16189514
Intra	WWP1	Q9H0M0	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	25416956
Intra	WWP1	Q9H0M0	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	25416956
Intra	WWP1	Q9H0M0	FBXL18	Homo sapiens	Q96D16	Validated Y2H	25416956
Intra	WWP1	Q9H0M0	FBXL18	Homo sapiens	Q96D16	Y2H Prey Pooling	25416956
Intra	WWP1	Q9H0M0	q8wu02_human	Homo sapiens	Q8WU02	Y2H Array	25416956
Intra	WWP1	Q9H0M0	q8wu02_human	Homo sapiens	Q8WU02	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Mucinous Carcinoma

Mucinous Carcinoma Of Breast

Invasive Mucinous Breast Carcinoma

Spastic Paraplegia 20, Autosomal Recessive

Troyer Syndrome	SPG20
Spastic Paraparesis, Childhood-Onset, With Distal Muscle Wasting	Spastic Paraplegia, Autosomal Recessive, Troyer Type
Autosomal Recessive Spastic Paraplegia Type 20	Autosomal Recessive Hereditary Spastic Paraplegia
Spastic Paraplegia 20	Cross-Mckusick Syndrome
Autosomal Recessive Spastic Paraplegia 20	Autosomal Recessive Spastic Paraplegia Troyer Type
Childhood-Onset Spastic Paraparesis With Distal Muscle Wasting	Hereditary Spastic Paraplegia 20
Spastic Paraplegia Type 20	Hereditary Spastic Paraplegia
Childhood-Onset Spastic Paraparesis-Distal Muscle Wasting Syndrome	Spastic Paraparesis Childhood-Onset With Distal Muscle Wasting
Spastic Paraplegia Autosomal Recessive Troyer Type	Trs
Spastic Paraplegia Hereditary Autosomal Recessive	Spastic Paraplegia, Hereditary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0170	Indole-3-carbinol		98.87%	Phase 3

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110204	Heclin	Inhibitor	98.21%	Unkown
HY-134417	NSC2805	Inhibitor	98.08%	Unkown
HY-168601	WWP1/2-IN-1	Inhibitor	/	Unkown
HY-168602	NSC-217913	Inhibitor	/	Unkown
HY-RS15860	WWP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WWP1	VGNC	VGNC:36978
Felis catus	WWP1	VGNC	VGNC:67099
Macaca mulatta	WWP1	VGNC	VGNC:104506
Mus musculus	WWP1	MGD	MGI:1861728
Canis familiaris	WWP1	VGNC	VGNC:48443
Rattus norvegicus	WWP1	RGD	RGD:1311734
Others	WWP1	NCBI

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