IMP4 - IMP U3 small nucleolar ribonucleoprotein 4 Gene

Homo sapiens

Also known as BXDC4

Gene ID: 92856 | Gene type: protein coding

About IMP4

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:130,342,897-130,347,967 (from NCBI)

This gene has 17 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 11.8), appendix (RPKM 9.3) and 25 other tissues.

Summary

The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

IMP4 Products(16)

mRNA	Protein	Name
NM_001320304.2	NP_001307233.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform b
NM_001320305.2	NP_001307234.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform c
NM_001320306.2	NP_001307235.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform d
NM_001320307.2	NP_001307236.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform d
NM_001320309.2	NP_001307238.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001320310.2	NP_001307239.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001320311.2	NP_001307240.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform f
NM_001371725.1	NP_001358654.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform g
NM_001371726.1	NP_001358655.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform h
NM_001371728.1	NP_001358657.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform i
NM_001371730.1	NP_001358659.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform j
NM_001371731.1	NP_001358660.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371732.1	NP_001358661.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371733.1	NP_001358662.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371734.1	NP_001358663.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_033416.3	NP_219484.1	U3 small nucleolar ribonucleoprotein protein IMP4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12655004	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Mpp10 complex	IDA IDA: Inferred from direct assay	12655004	GOA
part of Mpp10 complex	IPI IPI: Inferred from physical interaction	12655004	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12655004	GOA
part of preribosome	IDA IDA: Inferred from direct assay	12655004	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMP4 Protein Structure

Brix

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

U3 small nucleolar ribonucleoprotein protein IMP4

IMP4 homolog, U3 small nucleolar ribonucleoprotein

IMP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IMP4	Q96G21	ZBTB7B	Homo sapiens	O15156-2	Y2H Array	32296183
Intra	IMP4	Q96G21	ZBTB7B	Homo sapiens	O15156-2	Y2H Prey Pooling	32296183
Intra	IMP4	Q96G21	MPHOSPH10	Homo sapiens	O00566	Pull Down	12655004
Intra	IMP4	Q96G21	ZBTB7B	Homo sapiens	O15156	Validated Y2H	25416956
Intra	IMP4	Q96G21	ZBTB7B	Homo sapiens	O15156	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12826	IMB-XH1	Inhibitor	≥98.0%	Unkown
HY-RS06794	IMP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IMP4	MGD	MGI:106572
Felis catus	IMP4	VGNC	VGNC:62917
Bos taurus	IMP4	VGNC	VGNC:30183
Rattus norvegicus	IMP4	RGD	RGD:1308463
Macaca mulatta	IMP4	VGNC	VGNC:73689
Others	IMP4	NCBI

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