2. Gene
  3. ZBTB7B - zinc finger and BTB domain containing 7B Gene

ZBTB7B - zinc finger and BTB domain containing 7B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CKROX; THPOK; ZFP67; ZBTB15; ZFP-67; c-KROX; hcKROX; ZNF857B

Gene ID: 51043 | Gene type: protein coding

About ZBTB7B

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,001,750-155,018,523 (from NCBI)

This gene has 5 transcripts (splice variants), 190 orthologues and 28 paralogues. Broad expression in skin (RPKM 39.5), duodenum (RPKM 31.2) and 25 other tissues.

Summary

This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

ZBTB7B Products(7)

mRNA Protein Name
NM_001252406.3 NP_001239335.1 zinc finger and BTB domain-containing protein 7B isoform 2
NM_001256455.2 NP_001243384.1 zinc finger and BTB domain-containing protein 7B isoform 1
NM_001377451.1 NP_001364380.1 zinc finger and BTB domain-containing protein 7B isoform 2
NM_001377452.1 NP_001364381.1 zinc finger and BTB domain-containing protein 7B isoform 1
NM_001377453.1 NP_001364382.1 zinc finger and BTB domain-containing protein 7B isoform 1
NM_001377454.1 NP_001364383.1 zinc finger and BTB domain-containing protein 7B isoform 1
NM_001377455.1 NP_001364384.1 zinc finger and BTB domain-containing protein 7B isoform 1

ZBTB7B Protein Structure

BTB

BTB: BTB/POZ domain (24 - 144)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (363 - 385)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (389 - 413)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (416 - 440)

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  • 539 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 7B

T-helper-inducing POZ/Krueppel-like factor

Related Diseases

Diseases Alias
Malignant Essential Hypertension

Accelerated Essential Hypertension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15980 ZBTB7B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZBTB7B MGD MGI:102755
Canis familiaris ZBTB7B VGNC VGNC:48545
Macaca mulatta ZBTB7B VGNC VGNC:81609
Bos taurus ZBTB7B VGNC VGNC:37090
Rattus norvegicus ZBTB7B RGD RGD:1305963
Others ZBTB7B NCBI