ZBTB7B - zinc finger and BTB domain containing 7B Gene

Homo sapiens

Also known as CKROX; THPOK; ZFP67; ZBTB15; ZFP-67; c-KROX; hcKROX; ZNF857B

Gene ID: 51043 | Gene type: protein coding

About ZBTB7B

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,001,750-155,018,523 (from NCBI)

This gene has 5 transcripts (splice variants), 190 orthologues and 28 paralogues. Broad expression in skin (RPKM 39.5), duodenum (RPKM 31.2) and 25 other tissues.

Summary

This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

ZBTB7B Products(7)

mRNA	Protein	Name
NM_001252406.3	NP_001239335.1	zinc finger and BTB domain-containing protein 7B isoform 2
NM_001256455.2	NP_001243384.1	zinc finger and BTB domain-containing protein 7B isoform 1
NM_001377451.1	NP_001364380.1	zinc finger and BTB domain-containing protein 7B isoform 2
NM_001377452.1	NP_001364381.1	zinc finger and BTB domain-containing protein 7B isoform 1
NM_001377453.1	NP_001364382.1	zinc finger and BTB domain-containing protein 7B isoform 1
NM_001377454.1	NP_001364383.1	zinc finger and BTB domain-containing protein 7B isoform 1
NM_001377455.1	NP_001364384.1	zinc finger and BTB domain-containing protein 7B isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB7B Protein Structure

BTB

zf-H2C2_2

0
100
200
300
400
500
539 a.a.

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 7B

T-helper-inducing POZ/Krueppel-like factor

ZBTB7B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZBTB7B	O15156	q5jpt6_human	Homo sapiens	Q5JPT6	Validated Y2H	25416956
Intra	ZBTB7B	O15156	RPL9	Homo sapiens	P32969	Y2H Array	25416956
Intra	ZBTB7B	O15156	RPL9	Homo sapiens	P32969	Y2H Prey Pooling	25416956
Intra	ZBTB7B	O15156	MORF4L2	Homo sapiens	Q15014	Validated Y2H	25416956
Intra	ZBTB7B	O15156	GRB2	Homo sapiens	P62993	Validated Y2H	25416956
Intra	ZBTB7B	O15156	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	ZBTB7B	O15156	NCK2	Homo sapiens	O43639	Validated Y2H	25416956
Intra	ZBTB7B	O15156	ZBTB5	Homo sapiens	O15062	Validated Y2H	25416956
Intra	ZBTB7B	O15156	ZBTB5	Homo sapiens	O15062	Y2H Array	25416956
Intra	ZBTB7B	O15156	ZBTB5	Homo sapiens	O15062	Y2H Prey Pooling	25416956
Intra	ZBTB7B	O15156	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	25416956
Intra	ZBTB7B	O15156	SORBS3	Homo sapiens	O60504	Validated Y2H	25416956
Intra	ZBTB7B	O15156	SORBS3	Homo sapiens	O60504	Y2H Array	25416956
Intra	ZBTB7B	O15156	SYTL4	Homo sapiens	Q96C24	Y2H Array	25416956
Intra	ZBTB7B	O15156	BCL6	Homo sapiens	P41182	Y2H Array	25416956
Intra	ZBTB7B	O15156	IMP4	Homo sapiens	Q96G21	Y2H	21516116
Intra	ZBTB7B	O15156	IMP4	Homo sapiens	Q96G21	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Malignant Essential Hypertension

Accelerated Essential Hypertension

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15980	ZBTB7B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZBTB7B	MGD	MGI:102755
Canis familiaris	ZBTB7B	VGNC	VGNC:48545
Macaca mulatta	ZBTB7B	VGNC	VGNC:81609
Bos taurus	ZBTB7B	VGNC	VGNC:37090
Rattus norvegicus	ZBTB7B	RGD	RGD:1305963
Others	ZBTB7B	NCBI

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