2. Gene
  3. TRIP12 - thyroid hormone receptor interactor 12 Gene

TRIP12 - thyroid hormone receptor interactor 12 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ULF; MRD49; TRIPC; TRIP-12

Gene ID: 9320 | Gene type: protein coding

About TRIP12

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:229,763,837-229,923,186 (from NCBI)

This gene has 30 transcripts (splice variants), 215 orthologues, 24 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 48.5), thyroid (RPKM 17.6) and 24 other tissues.

Summary

The protein encoded by this gene is an E3 ubiquitin-protein Ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]

TRIP12 Products(26)

mRNA Protein Name
NM_001284214.2 NP_001271143.1 E3 ubiquitin-protein ligase TRIP12 isoform a
NM_001284215.2 NP_001271144.1 E3 ubiquitin-protein ligase TRIP12 isoform b
NM_001284216.2 NP_001271145.1 E3 ubiquitin-protein ligase TRIP12 isoform d
NM_001348315.2 NP_001335244.1 E3 ubiquitin-protein ligase TRIP12 isoform a
NM_001348316.2 NP_001335245.1 E3 ubiquitin-protein ligase TRIP12 isoform b
NM_001348317.1 NP_001335246.1 E3 ubiquitin-protein ligase TRIP12 isoform e
NM_001348318.2 NP_001335247.1 E3 ubiquitin-protein ligase TRIP12 isoform e
NM_001348319.1 NP_001335248.1 E3 ubiquitin-protein ligase TRIP12 isoform f
NM_001348320.2 NP_001335249.1 E3 ubiquitin-protein ligase TRIP12 isoform f
NM_001348321.1 NP_001335250.1 E3 ubiquitin-protein ligase TRIP12 isoform g
NM_001348322.1 NP_001335251.1 E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348323.3 NP_001335252.1 E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348324.2 NP_001335253.1 E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348325.2 NP_001335254.1 E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348326.2 NP_001335255.1 E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348327.2 NP_001335256.1 E3 ubiquitin-protein ligase TRIP12 isoform h
NM_001348328.1 NP_001335257.1 E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348329.2 NP_001335258.1 E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348330.2 NP_001335259.1 E3 ubiquitin-protein ligase TRIP12 isoform i
NM_001348331.1 NP_001335260.1 E3 ubiquitin-protein ligase TRIP12 isoform j
NM_001348332.1 NP_001335261.1 E3 ubiquitin-protein ligase TRIP12 isoform k
NM_001348333.1 NP_001335262.1 E3 ubiquitin-protein ligase TRIP12 isoform l
NM_001348334.1 NP_001335263.1 E3 ubiquitin-protein ligase TRIP12 isoform n
NM_001348335.2 NP_001335264.1 E3 ubiquitin-protein ligase TRIP12 isoform m
NM_001348336.1 NP_001335265.1 E3 ubiquitin-protein ligase TRIP12 isoform m
NM_004238.3 NP_004229.1 E3 ubiquitin-protein ligase TRIP12 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nuclear thyroid hormone receptor binding IDA
IDA: Inferred from direct assay
7776974 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18627766 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
18627766 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
19028681 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA repair-dependent chromatin remodeling IMP
IMP: Inferred from mutant phenotype
22884692 GOA
involved in heterochromatin boundary formation IMP
IMP: Inferred from mutant phenotype
22884692 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
30982744 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
18627766 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19028681 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
20208519 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP12 Protein Structure

HECT

HECT: HECT-domain (ubiquitin-transferase) (1637 - 1992)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1992 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIP12

E3 ubiquitin-protein ligase for Arf

Related Diseases

Diseases Alias
Clark-Baraitser Syndrome

CLABARS

Baraitser Syndrome

Autosomal Dominant Intellectual Disability 49

Mental Retardation, Autosomal Dominant 49, Formerly

Mrd49, Formerly

Intellectual Developmental Disorder, Autosomal Dominant 49

Autosomal Dominant Mental Retardation 49

Intellectual Disability, Tall Stature, Obesity, Macrocephaly And Typical Facial Features

Mrd49

Progeria Short Stature Pigmented Nevi
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Developmental And Epileptic Encephalopathy 17

DEE17

Epileptic Encephalopathy, Early Infantile, 17

Eiee17

Developmental And Epileptic Encephalopathy, 17

Early Infantile Epileptic Encephalopathy 17

Developmental And Epileptic Encephalopathy, Type 17
Thyroid Dyshormonogenesis 1

TDH1

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 1

Genetic Defect In Thyroid Hormonogenesis 1

Thyroid Hormonogenesis, Genetic Defect In, 1

Iodine Accumulation, Transport, Or Trapping Defect

Iodide Accumulation, Transport, Or Trapping Defect

Chdh1

Congenital Hypothyroidism Due To Dyshormonogenesis Type 1

Iodine Accumulation, Transport Or Trapping Defect
Alternating Exotropia

Exotropia
Anal Squamous Cell Carcinoma

Epidermoid Anal Carcinoma

Carcinoma Of Anal Margin
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15078 TRIP12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRIP12 VGNC VGNC:99414
Rattus norvegicus TRIP12 RGD RGD:1306607
Mus musculus TRIP12 MGD MGI:1309481
Canis familiaris TRIP12 VGNC VGNC:47845
Bos taurus TRIP12 VGNC VGNC:36358
Felis catus TRIP12 VGNC VGNC:66560