LEMD1 - LEM domain containing 1 Gene

Homo sapiens

Also known as CT50; LEMP-1

Gene ID: 93273 | Gene type: protein coding

About LEMD1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,381,378-205,449,966 (from NCBI)

This gene has 8 transcripts (splice variants), 145 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 16.5).

Summary

Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LEMD1 Products(4)

mRNA	Protein	Name
NM_001001552.5	NP_001001552.3	LEM domain-containing protein 1 isoform 3
NM_001199050.2	NP_001185979.1	LEM domain-containing protein 1 isoform 1
NM_001199051.2	NP_001185980.1	LEM domain-containing protein 1 isoform 2
NM_001199052.2	NP_001185981.1	LEM domain-containing protein 1 isoform 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LEMD1 Protein Structure

LEM

0
100
140 a.a.

Protein Preferred Names

Protein Names

LEM domain-containing protein 1

LEM domain protein 1

LEMD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LEMD1	Q68G75	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	LEMD1	Q68G75	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	LEMD1	Q68G75	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	LEMD1	Q68G75	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	LEMD1	Q68G75	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	TMPPE	Homo sapiens	Q6ZT21	Y2H Array	32296183
Intra	LEMD1	Q68G75	TMPPE	Homo sapiens	Q6ZT21	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	TMPPE	Homo sapiens	Q6ZT21	Validated Y2H	32296183
Intra	LEMD1	Q68G75	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	LEMD1	Q68G75	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	LEMD1	Q68G75	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	LEMD1	Q68G75	ERMAP	Homo sapiens	Q96PL5	Validated Y2H	32296183
Intra	LEMD1	Q68G75	ERMAP	Homo sapiens	Q96PL5	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	ERMAP	Homo sapiens	Q96PL5	Y2H Array	32296183
Intra	LEMD1	Q68G75	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	LEMD1	Q68G75	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	LEMD1	Q68G75	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	LEMD1	Q68G75	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	LEMD1	Q68G75	BLCAP	Homo sapiens	P62952	Y2H Array	32296183
Intra	LEMD1	Q68G75	BLCAP	Homo sapiens	P62952	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	LEMD1	Q68G75	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
Intra	LEMD1	Q68G75	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	LEMD1	Q68G75	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	LEMD1	Q68G75	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	LEMD1	Q68G75	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07587	LEMD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LEMD1	MGD	MGI:1922403
Bos taurus	LEMD1	VGNC	VGNC:30835
Macaca mulatta	LEMD1	VGNC	VGNC:99999
Felis catus	LEMD1	VGNC	VGNC:63210
Rattus norvegicus	LEMD1	RGD	RGD:2322707
Canis familiaris	LEMD1	VGNC	VGNC:42631

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