2. Gene
  3. MGST3 - microsomal glutathione S-transferase 3 Gene

MGST3 - microsomal glutathione S-transferase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GST-III

Gene ID: 4259 | Gene type: protein coding

About MGST3

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:165,631,234-165,656,136 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in heart (RPKM 114.7), fat (RPKM 75.6) and 24 other tissues.

Summary

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an Enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This Enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]

MGST3 Products(1)

mRNA Protein Name
NM_004528.4 NP_004519.1 microsomal glutathione S-transferase 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables glutathione peroxidase activity IDA
IDA: Inferred from direct assay
9278457 GOA
NOT enables glutathione transferase activity IDA
IDA: Inferred from direct assay
9278457 GOA
enables glutathione transferase activity IDA
IDA: Inferred from direct assay
36370807 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables leukotriene-C4 synthase activity IDA
IDA: Inferred from direct assay
9278457 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
9278457 GOA
involved in lipid metabolic process IDA
IDA: Inferred from direct assay
9278457 GOA
involved in prostanoid metabolic process IDA
IDA: Inferred from direct assay
36370807 GOA
Cellular Component GO Annotation Evidence Reference Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
9278457 GOA
located in membrane IDA
IDA: Inferred from direct assay
9278457 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
27184847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGST3 Protein Structure

MAPEG

MAPEG: MAPEG family (12 - 127)

  • 0
  • 100
  • 152 a.a.
Protein Preferred Names Protein Names

microsomal glutathione S-transferase 3

LTC4 synthase MGST3

MGST3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MGST3 O14880 GRM2 Homo sapiens Q14416
Validated Y2H
32296183
Intra
MGST3 O14880 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
Intra
MGST3 O14880 SNAP47 Homo sapiens Q5SQN1
Validated Y2H
32296183
Intra
MGST3 O14880 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra
MGST3 O14880 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
MGST3 O14880 PLPP4 Homo sapiens Q5VZY2
Validated Y2H
32296183
Intra
MGST3 O14880 TFAM Homo sapiens Q00059
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 TFAM Homo sapiens Q00059
Validated Y2H
32296183
Intra
MGST3 O14880 TFAM Homo sapiens Q00059
Y2H Array
32296183
Intra
MGST3 O14880 TFAM Homo sapiens Q00059
BioID
29568061
Intra
MGST3 O14880 TMEM109 Homo sapiens Q9BVC6
Validated Y2H
32296183
Intra
MGST3 O14880 SEC22B Homo sapiens O75396
Validated Y2H
32296183
Intra
MGST3 O14880 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Intra
MGST3 O14880 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
MGST3 O14880 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
MGST3 O14880 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
MGST3 O14880 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 SNORC Homo sapiens Q6UX34
Validated Y2H
32296183
Intra
MGST3 O14880 GIMAP1 Homo sapiens Q8WWP7
Validated Y2H
32296183
Intra
MGST3 O14880 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra
MGST3 O14880 TSPAN33 Homo sapiens Q86UF1
Validated Y2H
32296183
Intra
MGST3 O14880 NRAC Homo sapiens Q8N912
Validated Y2H
32296183
Intra
MGST3 O14880 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra
MGST3 O14880 PLP1 Homo sapiens P60201-2
Validated Y2H
32296183
Intra
MGST3 O14880 TMEM229B Homo sapiens Q8NBD8
Validated Y2H
32296183
Intra
MGST3 O14880 LEMD1 Homo sapiens Q68G75
Validated Y2H
32296183
Intra
MGST3 O14880 AQP10 Homo sapiens Q96PS8
Validated Y2H
32296183
Intra
MGST3 O14880 TMEM107 Homo sapiens Q6UX40
Validated Y2H
32296183
Intra
MGST3 O14880 SLC35A1 Homo sapiens P78382
Validated Y2H
32296183
Intra
MGST3 O14880 SYS1 Homo sapiens Q8N2H4
Validated Y2H
32296183
Intra
MGST3 O14880 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
MGST3 O14880 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
MGST3 O14880 STX3 Homo sapiens Q13277
Validated Y2H
32296183
Intra
MGST3 O14880 PPGB Homo sapiens Q59EV6
Validated Y2H
32296183
Intra
MGST3 O14880 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
MGST3 O14880 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
MGST3 O14880 CLRN1 Homo sapiens P58418
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 CLRN1 Homo sapiens P58418
Validated Y2H
32296183
Intra
MGST3 O14880 CLRN1 Homo sapiens P58418
Y2H Array
32296183
Intra
MGST3 O14880 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra
MGST3 O14880 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 TSPAN12 Homo sapiens O95859
Validated Y2H
32296183
Intra
MGST3 O14880 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
MGST3 O14880 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
MGST3 O14880 PAGE1 Homo sapiens O75459
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 PAGE1 Homo sapiens O75459
Validated Y2H
32296183
Intra
MGST3 O14880 PAGE1 Homo sapiens O75459
Y2H Array
32296183
Intra
MGST3 O14880 ITGAM Homo sapiens P11215
Validated Y2H
32296183
Intra
MGST3 O14880 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
MGST3 O14880 YIF1A Homo sapiens O95070
Validated Y2H
32296183
Intra
MGST3 O14880 ARL6IP6 Homo sapiens Q8N6S5
Validated Y2H
32296183
Intra
MGST3 O14880 AQP3 Homo sapiens Q92482
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 AQP3 Homo sapiens Q92482
Validated Y2H
32296183
Intra
MGST3 O14880 AQP3 Homo sapiens Q92482
Y2H Array
32296183
Intra
MGST3 O14880 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
Intra
MGST3 O14880 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra
MGST3 O14880 SLC39A9 Homo sapiens Q9NUM3
Y2H Array
32296183
Intra
MGST3 O14880 SLC39A9 Homo sapiens Q9NUM3
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 SLC2A5 Homo sapiens P22732
Validated Y2H
32296183
Intra
MGST3 O14880 LRP10 Homo sapiens Q7Z4F1
Validated Y2H
32296183
Intra
MGST3 O14880 C11orf24 Homo sapiens Q96F05
Validated Y2H
32296183
Intra
MGST3 O14880 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Intra
MGST3 O14880 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
MGST3 O14880 STX7 Homo sapiens O15400
Validated Y2H
32296183
Intra
MGST3 O14880 TFRC Homo sapiens P02786
Validated Y2H
32296183
Intra
MGST3 O14880 SLC1A3 Homo sapiens P43003
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 SLC1A3 Homo sapiens P43003
Validated Y2H
32296183
Intra
MGST3 O14880 SLC1A3 Homo sapiens P43003
Y2H Array
32296183
Intra
MGST3 O14880 TSPAN2 Homo sapiens O60636
Validated Y2H
32296183
Intra
MGST3 O14880 NKG7 Homo sapiens Q16617
Validated Y2H
32296183
Intra
MGST3 O14880 BMP10 Homo sapiens O95393
Validated Y2H
32296183
Intra
MGST3 O14880 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
MGST3 O14880 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
MGST3 O14880 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
Intra
MGST3 O14880 APOL2 Homo sapiens Q9BQE5
Validated Y2H
32296183
Intra
MGST3 O14880 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 MRM1 Homo sapiens Q6IN84
Validated Y2H
32296183
Intra
MGST3 O14880 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra
MGST3 O14880 PLP2 Homo sapiens Q04941
Validated Y2H
32296183
Intra
MGST3 O14880 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra
MGST3 O14880 GIMAP5 Homo sapiens Q96F15
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 NSG1 Homo sapiens P42857
Validated Y2H
32296183
Intra
MGST3 O14880 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
MGST3 O14880 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
MGST3 O14880 PLN Homo sapiens P26678
Validated Y2H
32296183
Intra
MGST3 O14880 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
MGST3 O14880 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
MGST3 O14880 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
MGST3 O14880 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
MGST3 O14880 HMOX2 Homo sapiens P30519
Validated Y2H
32296183
Intra
MGST3 O14880 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
MGST3 O14880 FUNDC2 Homo sapiens Q9BWH2
Validated Y2H
32296183
Intra
MGST3 O14880 ARL6IP1 Homo sapiens Q15041
Validated Y2H
32296183
Intra
MGST3 O14880 APOD Homo sapiens P05090
Validated Y2H
32296183
Intra
MGST3 O14880 ZFPL1 Homo sapiens O95159
Validated Y2H
32296183
Intra
MGST3 O14880 NEU1 Homo sapiens Q99519
Validated Y2H
32296183
Intra
MGST3 O14880 VAMP3 Homo sapiens Q15836
Validated Y2H
32296183
Intra
MGST3 O14880 BIRC6 Homo sapiens Q9NR09
Anti Tag CoIP
33961781
Intra
MGST3 O14880 BIRC6 Homo sapiens Q9NR09
BioID
29568061
Intra
MGST3 O14880 BIRC6 Homo sapiens Q9NR09
Anti Tag CoIP
28514442
Intra
MGST3 O14880 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
MGST3 O14880 VAMP4 Homo sapiens O75379
Validated Y2H
32296183
Intra
MGST3 O14880 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra
MGST3 O14880 BET1 Homo sapiens O15155
Validated Y2H
32296183
Intra
MGST3 O14880 UNC50 Homo sapiens Q53HI1
Validated Y2H
32296183
Intra
MGST3 O14880 MIP Homo sapiens P30301
Validated Y2H
32296183
Intra
MGST3 O14880 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
MGST3 O14880 CACNG1 Homo sapiens Q06432
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

MGST3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83478 MGST3 Antibody (YA3223) WB, IHC-P, IP Human

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08418 MGST3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MGST3 VGNC VGNC:68253
Bos taurus MGST3 VGNC VGNC:31453
Mus musculus MGST3 MGD MGI:1913697
Macaca mulatta MGST3 VGNC VGNC:74720
Canis familiaris MGST3 VGNC VGNC:53121
Rattus norvegicus MGST3 RGD RGD:1306373