MGST3 - microsomal glutathione S-transferase 3 Gene

Homo sapiens

Also known as GST-III

Gene ID: 4259 | Gene type: protein coding

About MGST3

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:165,631,234-165,656,136 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in heart (RPKM 114.7), fat (RPKM 75.6) and 24 other tissues.

Summary

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an Enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This Enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]

MGST3 Products(1)

mRNA	Protein	Name
NM_004528.4	NP_004519.1	microsomal glutathione S-transferase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutathione peroxidase activity	IDA IDA: Inferred from direct assay	9278457	GOA
NOT enables glutathione transferase activity	IDA IDA: Inferred from direct assay	9278457	GOA
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	36370807	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables leukotriene-C4 synthase activity	IDA IDA: Inferred from direct assay	9278457	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in leukotriene biosynthetic process	IDA IDA: Inferred from direct assay	9278457	GOA
involved in lipid metabolic process	IDA IDA: Inferred from direct assay	9278457	GOA
involved in prostanoid metabolic process	IDA IDA: Inferred from direct assay	36370807	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	9278457	GOA
located in membrane	IDA IDA: Inferred from direct assay	9278457	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	27184847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGST3 Protein Structure

MAPEG

0
100
152 a.a.

Protein Preferred Names

Protein Names

microsomal glutathione S-transferase 3

LTC4 synthase MGST3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08418	MGST3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MGST3	VGNC	VGNC:68253
Bos taurus	MGST3	VGNC	VGNC:31453
Mus musculus	MGST3	MGD	MGI:1913697
Macaca mulatta	MGST3	VGNC	VGNC:74720
Canis familiaris	MGST3	VGNC	VGNC:53121
Rattus norvegicus	MGST3	RGD	RGD:1306373

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