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  3. B4GALT5 - beta-1,4-galactosyltransferase 5 Gene

B4GALT5 - beta-1,4-galactosyltransferase 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as gt-V; B4Gal-T5; beta4Gal-T5; beta4GalT-V; BETA4-GALT-IV

Gene ID: 9334 | Gene type: protein coding

About B4GALT5

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,632,945-49,713,878 (from NCBI)

This gene has 1 transcript (splice variant), 223 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 36.1), adrenal (RPKM 25.6) and 24 other tissues.

Summary

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the Enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]

B4GALT5 Products(1)

mRNA Protein Name
NM_004776.4 NP_004767.1 beta-1,4-galactosyltransferase 5
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity IMP
IMP: Inferred from mutant phenotype
24498430 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

B4GALT5 Protein Structure

Glyco_transf_7N

Glyco_transf_7N: N-terminal region of glycosyl transferase group 7 (114 - 249)

Glyco_transf_7C

Glyco_transf_7C: N-terminal domain of galactosyltransferase (253 - 329)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

beta-1,4-galactosyltransferase 5

UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5

Related Diseases

Diseases Alias
Spindle Cell Liposarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114364 UDP-Galactose disodium Agonist 99.42% Unkown
HY-RS01323 B4GALT5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta B4GALT5 VGNC VGNC:70212
Felis catus B4GALT5 VGNC VGNC:68996
Canis familiaris B4GALT5 VGNC VGNC:38353
Rattus norvegicus B4GALT5 RGD RGD:1310062
Bos taurus B4GALT5 VGNC VGNC:26392
Mus musculus B4GALT5 MGD MGI:1927169