HSPA13 - heat shock protein family A (Hsp70) member 13 Gene

Homo sapiens

Also known as STCH

Gene ID: 6782 | Gene type: protein coding

About HSPA13

Cytogenetic location: 21q11.2 Genomic coordinates (GRCh38): 21:14,371,115-14,383,146 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 23.3), thyroid (RPKM 21.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]

HSPA13 Products(1)

mRNA	Protein	Name
NM_006948.5	NP_008879.3	heat shock 70 kDa protein 13 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA13 Protein Structure

HSP70

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 13

heat shock protein 70kDa family, member 13

HSPA13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Fragment Pooling	35914814
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	HSPA13	P48723	CRYGA	Homo sapiens	Q24JT5	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	CRYGA	Homo sapiens	Q24JT5	Validated Y2H	32296183
Intra	HSPA13	P48723	CRYGA	Homo sapiens	Q24JT5	Y2H Array	32296183
Intra	HSPA13	P48723	B4GALT5	Homo sapiens	O43286	Anti Tag CoIP	28514442
Intra	HSPA13	P48723	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	HSPA13	P48723	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	HSPA13	P48723	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	HSPA13	P48723	UBQLN4	Homo sapiens	Q9NRR5	Y2H Array	16713569
Intra	HSPA13	P48723	UBQLN4	Homo sapiens	Q9NRR5	Y2H Fragment Pooling	35914814
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	25416956
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	HSPA13	P48723	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	16189514
Intra	HSPA13	P48723	SGTB	Homo sapiens	Q96EQ0	Y2H Fragment Pooling	35914814
Intra	HSPA13	P48723	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	HSPA13	P48723	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	HSPA13	P48723	UBQLN2	Homo sapiens	Q9UHD9	Y2H Fragment Pooling	35914814
Intra	HSPA13	P48723	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	HSPA13	P48723	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	HSPA13	P48723	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bartter Syndrome, Type 1, Antenatal

Hyperprostaglandin E Syndrome 1	Bartter Disease Type 1
BARTS1	Bartter Syndrome, Type 1
Bartter Syndrome Type 1	Hypokalemic Alkalosis With Hypercalciuria Antenatal 1
Hypokalemic Alkalosis With Hypercalciuria 1, Antenatal	Bartter Syndrome Type 1 Antenatal
Hypokalemic Alkalosis With Hypercalciuria 1 Antenatal	Bartter Syndrome Antenatal Type 1
Antenatal Bartter Syndrome Type 1	Bartter Syndrome Type I
Bartter Syndrome 1, Antenatal	Abs1
Antenatal Bartter Syndrome 1	Bs1
Bartter Syndrome, Antenatal Type 1	Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis

Deafness, Autosomal Dominant 28

DFNA28	Autosomal Dominant Nonsyndromic Deafness 28
Autosomal Dominant Deafness 28	Deafness, Autosomal Dominant, 28
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 28	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 28
Deafness, Autosomal Dominant, Type 28

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06422	HSPA13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HSPA13	VGNC	VGNC:102758
Bos taurus	HSPA13	VGNC	VGNC:53581
Macaca mulatta	HSPA13	VGNC	VGNC:81327
Rattus norvegicus	HSPA13	RGD	RGD:3775
Mus musculus	HSPA13	MGD	MGI:1309463
Canis familiaris	HSPA13	VGNC	VGNC:53026
Others	HSPA13	NCBI

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