SLC22A6 - solute carrier family 22 member 6 Gene

Homo sapiens

Also known as OAT1; PAHT; HOAT1; ROAT1

Gene ID: 9356 | Gene type: protein coding

About SLC22A6

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,976,597-62,984,967 (from NCBI)

This gene has 6 transcripts (splice variants), 489 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 150.9).

Summary

The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SLC22A6 Products(4)

mRNA	Protein	Name
NM_004790.5	NP_004781.2	solute carrier family 22 member 6 isoform a
NM_153276.3	NP_695008.1	solute carrier family 22 member 6 isoform b
NM_153277.3	NP_695009.1	solute carrier family 22 member 6 isoform c
NM_153278.3	NP_695010.1	solute carrier family 22 member 6 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-ketoglutarate transmembrane transporter activity	IDA IDA: Inferred from direct assay	9950961	GOA
enables antiporter activity	IDA IDA: Inferred from direct assay	9950961	GOA
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9950961	GOA
enables organic anion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	22169006	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: Inferred from direct assay	11907186	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sodium-independent organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9887087	GOA
enables solute:inorganic anion antiporter activity	IDA IDA: Inferred from direct assay	15037815	GOA
enables transmembrane transporter activity	IDA IDA: Inferred from direct assay	26377792	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	14675047	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in alpha-ketoglutarate transport	IDA IDA: Inferred from direct assay	9950961	GOA
involved in organic anion transport	IDA IDA: Inferred from direct assay	9950961	GOA
involved in organic anion transport	IMP IMP: Inferred from mutant phenotype	22169006	GOA
involved in prostaglandin transport	IDA IDA: Inferred from direct assay	11907186	GOA
involved in renal tubular secretion	IMP IMP: Inferred from mutant phenotype	22169006	GOA
involved in sodium-independent organic anion transport	IDA IDA: Inferred from direct assay	9887087	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	35307651	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9887087	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14749323	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A6 Protein Structure

Sugar_tr

0
100
200
300
400
500
563 a.a.

Protein Preferred Names

Protein Names

solute carrier family 22 member 6

PAH transporter

SLC22A6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC22A6	Q4U2R8	APPBP2	Homo sapiens	Q92624	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hyperuricemia

Blood Urate Raized

Uricacidemia

Fanconi-Like Syndrome

Fanconi Like Syndrome

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Acute Kidney Failure

Acute Renal Failure	Acute Kidney Injury
Renal Failure Acute	Kidney Failure, Acute
Pre-Renal Acute Kidney Injury	Nontraumatic Acute Kidney Injury
Aki - [Acute Kidney Injury]	Arf - [Acute Kidney Failure]
Acute Kidney Disease	Acute Kidney Impairment
Acute Ischaemic Renal Failure	Acute Hypoxic Kidney Failure
Acute Kidney Shutdown	Acute Renal Oedema
Acute Renal Impairment	Acute Kidney Collapse
Acute Necrotising Kidney	Acute Renal Suppression

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13078	SLC22A6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC22A6	RGD	RGD:69338
Felis catus	SLC22A6	VGNC	VGNC:104330
Macaca mulatta	SLC22A6	VGNC	VGNC:77421
Canis familiaris	SLC22A6	VGNC	VGNC:46280
Mus musculus	SLC22A6	MGD	MGI:892001
Others	SLC22A6	NCBI

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