ZFYVE9 - zinc finger FYVE-type containing 9 Gene

Homo sapiens

Also known as NSP; SARA; MADHIP; SMADIP; PPP1R173

Gene ID: 9372 | Gene type: protein coding

About ZFYVE9

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,142,089-52,346,634 (from NCBI)

This gene has 5 transcripts (splice variants) and 268 orthologues. Ubiquitous expression in brain (RPKM 8.0), thyroid (RPKM 7.9) and 25 other tissues.

Summary

This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

ZFYVE9 Products(2)

mRNA	Protein	Name
NM_004799.4	NP_004790.2	zinc finger FYVE domain-containing protein 9 isoform 3
NM_007324.5	NP_015563.2	zinc finger FYVE domain-containing protein 9 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol binding	IDA IDA: Inferred from direct assay	11877415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9865696	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15231848	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9865696	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	11877415	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15231848	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE9 Protein Structure

FYVE

SARA

DUF3480

0
300
600
900
1200
1425 a.a.

Protein Preferred Names

Protein Names

zinc finger FYVE domain-containing protein 9

MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor

ZFYVE9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFYVE9	O95405	SMAD2	Homo sapiens	Q15796	Anti Tag CoIP	10615055
Intra	ZFYVE9	O95405	SMAD2	Homo sapiens	Q15796	Confocal	10615055
Intra	ZFYVE9	O95405	SMAD2	Homo sapiens	Q15796	X-Ray Diffraction	10615055
Intra	ZFYVE9	O95405	SMAD2	Homo sapiens	Q15796	Affinity Techniques	10615055
Intra	ZFYVE9	O95405	RHO	Homo sapiens	P08100	Anti Bait CoIP	17693260
Intra	ZFYVE9	O95405	STX3	Homo sapiens	Q13277	Confocal	17693260
Intra	ZFYVE9	O95405	LRP12	Homo sapiens	Q9Y561	Y2H	12809483
Intra	ZFYVE9	O95405	LRP12	Homo sapiens	Q9Y561	Anti Tag CoIP	12809483
Intra	ZFYVE9	O95405	SMAD3	Homo sapiens	P84022	Y2H	15231748
Intra	ZFYVE9	O95405	SMAD3	Homo sapiens	P84022	Y2H Array	25502805
Intra	ZFYVE9	O95405	SMAD3	Homo sapiens	P84022	Y2H Array	31515488
Intra	ZFYVE9	O95405	PPP1CC	Homo sapiens	P36873	Y2H	15231748
Intra	ZFYVE9	O95405	PPP1CC	Homo sapiens	P36873	Y2H Array	25416956
Intra	ZFYVE9	O95405	PPP1CA	Homo sapiens	P62136	Y2H	15231748
Intra	ZFYVE9	O95405	PPP1CA	Homo sapiens	P62136	Y2H	22321011

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Iga Glomerulonephritis

Iga Nephropathy	Glomerulonephritis, Iga
Berger'S Iga Or Igg Nephropathy	Focal Glomerulonephritis
Primary Iga Nephropathy	Segmental Glomerulonephritis
Berger Disease	Berger'S Disease
Igan	Nephritis, Iga Type
Nephropathy Iga	Glomerulonephritis Focal
Iga Nephropathy, Susceptibility To	Primary Immunoglobulin A Nephropathy

Nanophthalmos

Nanophthalmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16062	ZFYVE9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZFYVE9	VGNC	VGNC:82272
Bos taurus	ZFYVE9	VGNC	VGNC:37179
Felis catus	ZFYVE9	VGNC	VGNC:68135
Rattus norvegicus	ZFYVE9	RGD	RGD:1310856
Canis familiaris	ZFYVE9	VGNC	VGNC:48628
Mus musculus	ZFYVE9	MGD	MGI:2652838

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