SYAP1 - synapse associated protein 1 Gene

Homo sapiens

Also known as BSTA; PRO3113

Gene ID: 94056 | Gene type: protein coding

About SYAP1

This gene has 2 transcripts (splice variants), 237 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 23.9), colon (RPKM 16.3) and 25 other tissues.

Summary

Involved in several processes, including TORC2 signaling; cellular response to growth factor stimulus; and cellular response to peptide hormone stimulus. Located in Golgi apparatus; cytosol; and nucleoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SYAP1 Products(1)

mRNA	Protein	Name
NM_032796.4	NP_116185.2	synapse-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in TORC2 signaling	IMP IMP: Inferred from mutant phenotype	23300339	GOA
involved in cellular response to epidermal growth factor stimulus	IMP IMP: Inferred from mutant phenotype	23300339	GOA
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	23300339	GOA
involved in cellular response to insulin-like growth factor stimulus	IMP IMP: Inferred from mutant phenotype	23300339	GOA
involved in cellular response to platelet-derived growth factor stimulus	IMP IMP: Inferred from mutant phenotype	23300339	GOA
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23300339	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	23300339	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	23300339	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYAP1 Protein Structure

BSD

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

synapse-associated protein 1

BSD domain-containing signal transducer and Akt interactor protein

SYAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SYAP1	Q96A49	PIN1	Homo sapiens	Q13526	Anti Tag CoIP	33961781
Intra	SYAP1	Q96A49	PIN1	Homo sapiens	Q13526	Anti Tag CoIP	28514442
Intra	SYAP1	Q96A49	NDN	Homo sapiens	Q99608	Anti Tag CoIP	32529326
Intra	SYAP1	Q96A49	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pettigrew Syndrome

PGS	Mrxs5
Mrx59	Mrxs21
X-Linked Intellectual Disability-Dandy-Walker Malformation-Basal Ganglia Disease-Seizures Syndrome	Mental Retardation, X-Linked, Syndromic 5
Mrxsf	Syndromic X-Linked Intellectual Disability 5
Fried Syndrome	Mental Retardation, X-Linked Syndromic 5
Mental Retardation, X-Linked, With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures	Mental Retardation, X-Linked, Syndromic, Fried Type
Mental Retardation, X-Linked, Syndromic 21	Syndromic X-Linked Mental Retardation 21
Syndromic X-Linked Mental Retardation Fried Type	X-Linked Metal Retardation With Dandy-Walker Malformation, Basal Ganglia Disease, And Seizures
Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease An	Dandy-Walker Malformation With Intellectual Disability, Basal Ganglia Disease And Seizures
X-Linked Syndromic Intellectual Disability 5	X-Linked Intellectual Disability With Dandy-Walker Malformation Basal Ganglia Disease And Seizures
X-Linked Intellectual Disability - Dandy-Walker Malformation - Basal Ganglia Disease - Seizures	X-Linked Intellectual Disability-Hypotonia-Facial Dysmorphism-Aggressive Behavior Syndrome
Mental Retardation, X-Linked Syndromic, Fried Type	Dandy-Walker Malformation With Mental Retardation, Basal Ganglia Disease, And Seizures
Mental Retardation, X-Linked 59

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14066	SYAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SYAP1	MGD	MGI:1914293
Canis familiaris	SYAP1	VGNC	VGNC:47012
Rattus norvegicus	SYAP1	RGD	RGD:1303113
Felis catus	SYAP1	VGNC	VGNC:65870
Macaca mulatta	SYAP1	VGNC	VGNC:78135
Bos taurus	SYAP1	VGNC	VGNC:35502

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