SNRNP40 - small nuclear ribonucleoprotein U5 subunit 40 Gene

Homo sapiens

Also known as 40K; SPF38; WDR57; PRP8BP; HPRP8BP; PRPF8BP

Gene ID: 9410 | Gene type: protein coding

About SNRNP40

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,259,568-31,296,788 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 26 paralogues. Ubiquitous expression in lymph node (RPKM 17.2), testis (RPKM 14.1) and 25 other tissues.

Summary

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008]

SNRNP40 Products(1)

mRNA	Protein	Name
NM_004814.3	NP_004805.2	U5 small nuclear ribonucleoprotein 40 kDa protein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9774689	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRNP40 Protein Structure

WD40

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

U5 small nuclear ribonucleoprotein 40 kDa protein

38 kDa-splicing factor

SNRNP40 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNRNP40	Q96DI7	SNRNP200	Homo sapiens	O75643	Anti Tag CoIP	33961781
Intra	SNRNP40	Q96DI7	SNRNP200	Homo sapiens	O75643	Anti Tag CoIP	28514442
Intra	SNRNP40	Q96DI7	SNRNP200	Homo sapiens	O75643	Anti Tag CoIP	35271311
Intra	SNRNP40	Q96DI7	SNRNP200	Homo sapiens	O75643	Anti Bait CoIP	17353931
Intra	SNRNP40	Q96DI7	EFTUD2	Homo sapiens	Q15029	Anti Tag CoIP	28514442
Intra	SNRNP40	Q96DI7	EFTUD2	Homo sapiens	Q15029	Anti Tag CoIP	35271311
Intra	SNRNP40	Q96DI7	EFTUD2	Homo sapiens	Q15029	Anti Bait CoIP	17353931
Intra	SNRNP40	Q96DI7	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	SNRNP40	Q96DI7	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	SNRNP40	Q96DI7	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	SNRNP40	Q96DI7	PRPF8	Homo sapiens	Q6P2Q9	Anti Bait CoIP	9774689
Intra	SNRNP40	Q96DI7	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	33961781
Intra	SNRNP40	Q96DI7	PRPF8	Homo sapiens	Q6P2Q9	Far-WB	9774689
Intra	SNRNP40	Q96DI7	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	28514442
Intra	SNRNP40	Q96DI7	PRPF8	Homo sapiens	Q6P2Q9	Anti Tag CoIP	35271311
Intra	SNRNP40	Q96DI7	PRPF8	Homo sapiens	Q6P2Q9	Anti Bait CoIP	17353931
Intra	SNRNP40	Q96DI7	DDX23	Homo sapiens	Q9BUQ8	Anti Tag CoIP	35271311
Intra	SNRNP40	Q96DI7	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	SNRNP40	Q96DI7	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	SNRNP40	Q96DI7	GFAP	Homo sapiens	P14136	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Burn-Mckeown Syndrome

Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome	Oculootofacial Dysplasia
BMKS	Oofd
Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance	Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome
Choanal Atresia Deafness Cardiac Defects Dysmorphism	Oculo-Oto-Facial Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13498	SNRNP40 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNRNP40	MGD	MGI:1913835
Felis catus	SNRNP40	VGNC	VGNC:65534
Bos taurus	SNRNP40	VGNC	VGNC:35071
Rattus norvegicus	SNRNP40	RGD	RGD:1309198
Macaca mulatta	SNRNP40	VGNC	VGNC:100144
Canis familiaris	SNRNP40	VGNC	VGNC:46607

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