Rab14 - RAB14, member RAS oncogene family Gene

Rattus norvegicus

Gene ID: 94197 | Gene type: protein coding

About Rab14

Summary

Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and Myosin V binding activity. Involved in apical protein localization; body fluid secretion; and regulation of protein localization. Located in several cellular components, including Golgi stack; apical plasma membrane; and cytoplasmic vesicle. Is anchored component of synaptic vesicle membrane. Orthologous to human RAB14 (RAB14, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab14 Products(1)

mRNA	Protein	Name
NM_053589.2	NP_446041.2	ras-related protein Rab-14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18332131	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in apical protein localization	IDA IDA: Inferred from direct assay	18429929	RGD
involved in body fluid secretion	IMP IMP: Inferred from mutant phenotype	18332131	RGD
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	18429929	RGD
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	18701652	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi stack	IDA IDA: Inferred from direct assay	15004230	RGD
located in alveolar lamellar body	IDA IDA: Inferred from direct assay	18332131	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18429929	RGD
located in cytosol	IDA IDA: Inferred from direct assay	15004230	RGD
located in early endosome	IDA IDA: Inferred from direct assay	15004230	RGD
located in late endosome	IDA IDA: Inferred from direct assay	15004230	RGD
located in lysosome	IDA IDA: Inferred from direct assay	15004230	RGD
located in nuclear outer membrane-endoplasmic reticulum membrane network	IDA IDA: Inferred from direct assay	15004230	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15004230	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	15004230	RGD
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	15004230	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	20926670	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	20926670	RGD
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	20926670	RGD
located in trans-Golgi network transport vesicle	IDA IDA: Inferred from direct assay	15004230	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-14

GTPase Rab14

Rab14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Rab14	P61107	NISCH	Homo sapiens	Q9Y2I1	Pull Down	23386062
Cross	Rab14	P61107	NISCH	Homo sapiens	Q9Y2I1	CoIP	23386062
Cross	Rab14	P61107	NISCH	Homo sapiens	Q9Y2I1	IF	23386062

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11523	RAB14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab14	NCBI	NCBI:51552

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