SIGLEC6 - sialic acid binding Ig like lectin 6 Gene

Homo sapiens

Also known as CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327

Gene ID: 946 | Gene type: protein coding

About SIGLEC6

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,517,819-51,531,670 (from NCBI)

This gene has 9 transcripts (splice variants), 66 orthologues and 16 paralogues. Biased expression in placenta (RPKM 50.1) and lung (RPKM 2.3).

Summary

This gene encodes a member of the Siglec (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and Leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

SIGLEC6 Products(6)

mRNA	Protein	Name
NM_001177547.3	NP_001171018.1	sialic acid-binding Ig-like lectin 6 isoform 4
NM_001177548.3	NP_001171019.1	sialic acid-binding Ig-like lectin 6 isoform 5 precursor
NM_001177549.3	NP_001171020.1	sialic acid-binding Ig-like lectin 6 isoform 6 precursor
NM_001245.7	NP_001236.4	sialic acid-binding Ig-like lectin 6 isoform 1 precursor
NM_198845.6	NP_942142.3	sialic acid-binding Ig-like lectin 6 isoform 2 precursor
NM_198846.6	NP_942143.3	sialic acid-binding Ig-like lectin 6 isoform 3 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25187624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC6 Protein Structure

V-set

I-set

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

sialic acid-binding Ig-like lectin 6

CD33 antigen-like 1

SIGLEC6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIGLEC6	O43699	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	SIGLEC6	O43699	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	SIGLEC6	O43699	TCF4	Homo sapiens	P15884	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGLEC6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71031	Siglec-6 Protein, Human (HEK293, Fc)	O43699-3 (E27-V331)	≥95%
HY-P700825	Siglec-6 Protein, Human (HEK293, His-Avi)	O43699-3 (Q27-V331)	≥95%

Related Diseases

Diseases

Alias

Non-Gestational Choriocarcinoma

Choriocarcinoma, Non-Gestational

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12904	SIGLEC6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIGLEC6	MGD	MGI:99440
Rattus norvegicus	SIGLEC6	RGD	RGD:1305432
Macaca mulatta	SIGLEC6	VGNC	VGNC:77216
Others	SIGLEC6	NCBI

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