2. Gene
  3. CXCL14 - C-X-C motif chemokine ligand 14 Gene

CXCL14 - C-X-C motif chemokine ligand 14 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14

Gene ID: 9547 | Gene type: protein coding

About CXCL14

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,570,679-135,578,991 (from NCBI)

This gene has 2 transcripts (splice variants) and 194 orthologues. Biased expression in skin (RPKM 295.1), kidney (RPKM 161.0) and 13 other tissues.

Summary

This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

CXCL14 Products(1)

mRNA Protein Name
NM_004887.5 NP_004878.3 C-X-C motif chemokine 14 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
12949249 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
12949249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL14 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (35 - 97)

  • 0
  • 100
  • 111 a.a.
Protein Preferred Names Protein Names

C-X-C motif chemokine 14

CXC chemokine in breast and kidney

CXCL14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CXCL14 O95715 PF4 Homo sapiens P02776
SPR
28381538
Intra
CXCL14 O95715 PF4 Homo sapiens P02776
Filter Binding
28381538
Intra
CXCL14 O95715 CCL5 Homo sapiens P13501
SPR
28381538
Intra
CXCL14 O95715 CCL5 Homo sapiens P13501
Filter Binding
28381538
Intra
CXCL14 O95715 CXCL11 Homo sapiens O14625
Filter Binding
28381538
Intra
CXCL14 O95715 CXCL9 Homo sapiens Q07325
Filter Binding
28381538
Intra
CXCL14 O95715 CXCL12 Homo sapiens P48061
Filter Binding
28381538
Intra
CXCL14 O95715 CXCL12 Homo sapiens P48061
SPR
28381538
Intra
CXCL14 O95715 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
CXCL14 O95715 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
CXCL14 O95715 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
Intra
CXCL14 O95715 CCL26 Homo sapiens Q9Y258
Filter Binding
28381538
Intra
CXCL14 O95715 CCL21 Homo sapiens O00585
Filter Binding
28381538
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCL14 Proteins

Cat. No. Product Name Accession Purity
HY-P72683 CXCL14/BRAK Protein, Human O95715 (S35-E111) ≥95%
HY-P75315 CXCL14/BRAK Protein, Human (Biotinylated) O95715 (S35-E111) ≥95%

Related Diseases

Diseases Alias
Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix
Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03388 CXCL14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CXCL14 VGNC VGNC:39748
Rattus norvegicus CXCL14 RGD RGD:1307406
Felis catus CXCL14 VGNC VGNC:61297
Macaca mulatta CXCL14 VGNC VGNC:71394
Bos taurus CXCL14 VGNC VGNC:27850
Mus musculus CXCL14 MGD MGI:1888514
Others CXCL14 NCBI