ATP6V1G1 - ATPase H+ transporting V1 subunit G1 Gene

Homo sapiens

Also known as ATP6G; ATP6J; Vma10; ATP6G1; ATP6GL

Gene ID: 9550 | Gene type: protein coding

About ATP6V1G1

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,587,769-114,598,879 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 73.2), adrenal (RPKM 65.5) and 25 other tissues.

Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008]

ATP6V1G1 Products(1)

mRNA	Protein	Name
NM_004888.4	NP_004879.1	V-type proton ATPase subunit G 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	17360703	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to increased oxygen levels	IMP IMP: Inferred from mutant phenotype	28296633	GOA
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	28296633	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17360703	GOA
part of vacuolar proton-transporting V-type ATPase, V1 domain	IDA IDA: Inferred from direct assay	33065002	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP6V1G1 Protein Structure

V-ATPase_G

0
100
118 a.a.

Protein Preferred Names

Protein Names

V-type proton ATPase subunit G 1

ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J

ATP6V1G1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATP6V1G1	O75348	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	ATP6V1G1	O75348	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	ATP6V1G1	O75348	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	ATP6V1G1	O75348	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	ATP6V1G1	O75348	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	ATP6V1G1	O75348	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	32296183
Intra	ATP6V1G1	O75348	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	ATP6V1G1	O75348	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	ATP6V1G1	O75348	ATP6V1E1	Homo sapiens	P36543	Anti Tag CoIP	35271311
Intra	ATP6V1G1	O75348	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	ATP6V1G1	O75348	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	ATP6V1G1	O75348	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	ATP6V1G1	O75348	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	ATP6V1G1	O75348	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	ATP6V1G1	O75348	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	ATP6V1G1	O75348	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	ATP6V1G1	O75348	LDOC1	Homo sapiens	O95751	Validated Y2H	25416956
Intra	ATP6V1G1	O75348	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	ATP6V1G1	O75348	ATP6V1E2	Homo sapiens	Q96A05	Y2H Prey Pooling	32296183
Intra	ATP6V1G1	O75348	ATP6V1E2	Homo sapiens	Q96A05	Validated Y2H	25416956
Intra	ATP6V1G1	O75348	ATP6V1E2	Homo sapiens	Q96A05	Validated Y2H	32296183
Intra	ATP6V1G1	O75348	ATP6V1E2	Homo sapiens	Q96A05	Y2H Array	32296183
Intra	ATP6V1G1	O75348	ATP6V1E2	Homo sapiens	Q96A05	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Optic Atrophy 6

OPA6	Optic Atrophy, Congenital Or Early Infantile, Autosomal Recessive

Distal Renal Tubular Acidosis

Classic Rta	Familial Distal Primary Acidosis
Renal Tubular Acidosis Type 1	Drta
Renal Tubular Acidosis, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01231	ATP6V1G1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ATP6V1G1	VGNC	VGNC:26324
Rattus norvegicus	ATP6V1G1	RGD	RGD:1310088
Macaca mulatta	ATP6V1G1	VGNC	VGNC:104876
Mus musculus	ATP6V1G1	MGD	MGI:1913540

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