2. Gene
  3. AATK - apoptosis associated tyrosine kinase Gene

AATK - apoptosis associated tyrosine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LMR1; AATYK; LMTK1; p35BP; AATYK1; PPP1R77

Gene ID: 9625 | Gene type: protein coding

About AATK

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,117,295-81,166,221 (from NCBI)

This gene has 11 transcripts (splice variants), 258 orthologues and 1 paralogue. Biased expression in brain (RPKM 12.1), duodenum (RPKM 7.0) and 11 other tissues.

Summary

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during Apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or Apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

AATK Products(2)

mRNA Protein Name
NM_001080395.3 NP_001073864.2 serine/threonine-protein kinase LMTK1 isoform 1
NM_004920.3 NP_004911.2 serine/threonine-protein kinase LMTK1 isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14521924 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AATK Protein Structure

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (128 - 393)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1374 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase LMTK1

CDK5-binding protein

AATK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AATK Q6ZMQ8 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
AATK Q6ZMQ8 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
AATK Q6ZMQ8 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra
AATK Q6ZMQ8 PPP1CC Homo sapiens P36873
Anti Tag CoIP
25852190
Intra
AATK Q6ZMQ8 PPP1CC Homo sapiens P36873
Affinity Chrom
35384245
Intra
AATK Q6ZMQ8 PPP1CA Homo sapiens P62136
Y2H
22321011
Intra
AATK Q6ZMQ8 PPP1CA Homo sapiens P62136
Anti Tag CoIP
25852190
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00035 AATK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AATK MGD MGI:1197518
Felis catus AATK VGNC VGNC:59459
Bos taurus AATK VGNC VGNC:25453
Rattus norvegicus AATK RGD RGD:1590980
Macaca mulatta AATK VGNC VGNC:69488
Others AATK NCBI