NUP155 - nucleoporin 155 Gene

Homo sapiens

Also known as N155; ATFB15

Gene ID: 9631 | Gene type: protein coding

About NUP155

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:37,288,137-37,371,106 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 44.4), bone marrow (RPKM 5.5) and 19 other tissues.

Summary

Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

NUP155 Products(3)

mRNA	Protein	Name
NM_001278312.2	NP_001265241.1	nuclear pore complex protein Nup155 isoform 3
NM_004298.4	NP_004289.1	nuclear pore complex protein Nup155 isoform 2
NM_153485.3	NP_705618.1	nuclear pore complex protein Nup155 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within nuclear envelope organization	IDA IDA: Inferred from direct assay	19070573	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	19070573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP155 Protein Structure

Nucleoporin_N

Nucleoporin_C

0
300
600
900
1200
1391 a.a.

Protein Preferred Names

Protein Names

nuclear pore complex protein Nup155

155 kDa nucleoporin

NUP155 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Anti Bait CoIP	30488537
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Confocal	30488537
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Pull Down	30488537

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Atrial Fibrillation, Familial, 15

ATFB15	Atrial Fibrillation 15
Fibrillation, Atrial, Familial, Type 15

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Atrial Fibrillation

A-Fib	Fibrillation, Atrial
Af - [Atrial Fibrillation]	Rapid Atrial Fibrillation
A Fib - [Atrial Fibrillation]

Lethal Congenital Contracture Syndrome 1

LCCS1	Multiple Contracture Syndrome, Finnish Type
Lccs	Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures
Lethal Congenital Contracture Syndrome Type 1	Herva Disease
Multiple Contracture Syndrome Finnish Type	Contracture Syndrome, Lethal, Congenital, Type 1

Anterior Horn Cell Disease

Lethal Congenital Contracture Syndrome

Lccs	Lethal Congenital Contracture Syndrome 1

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09686	NUP155 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NUP155	VGNC	VGNC:44046
Macaca mulatta	NUP155	VGNC	VGNC:84456
Bos taurus	NUP155	VGNC	VGNC:32352
Mus musculus	NUP155	MGD	MGI:2181182
Felis catus	NUP155	VGNC	VGNC:102275
Rattus norvegicus	NUP155	RGD	RGD:621199

Name
Email *

	Sorry, but the email address you supplied was invalid.