RAB11FIP3 - RAB11 family interacting protein 3 Gene

Homo sapiens

Also known as CART1; FIP3-Rab11; Rab11-FIP3

Gene ID: 9727 | Gene type: protein coding

About RAB11FIP3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:425,649-523,011 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 204 orthologues and 1 paralogue. Broad expression in kidney (RPKM 33.4), brain (RPKM 8.0) and 25 other tissues.

Summary

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]

RAB11FIP3 Products(3)

mRNA	Protein	Name
NM_001142272.2	NP_001135744.2	rab11 family-interacting protein 3 isoform 2
NM_001370401.1	NP_001357330.1	rab11 family-interacting protein 3 isoform 3
NM_014700.4	NP_055515.1	rab11 family-interacting protein 3 isoform 1

RAB11FIP3 Protein Structure

EF-hand_7

RBD-FIP

0
200
400
600
756 a.a.

Protein Preferred Names

Protein Names

rab11 family-interacting protein 3

EF hands-containing Rab-interacting protein

RAB11FIP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB11FIP3	O75154	RACGAP1	Homo sapiens	Q9H0H5	IF	18511905
Intra	RAB11FIP3	O75154	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	18511905
Intra	RAB11FIP3	O75154	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	18511905
Intra	RAB11FIP3	O75154	RACGAP1	Homo sapiens	Q9H0H5	Pull Down	18511905
Intra	RAB11FIP3	O75154	RACGAP1	Homo sapiens	Q9H0H5	Competition Binding	18511905

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Muscular Dystrophy-Dystroglycanopathy A7

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A7	Mddga7
Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease Ispd-Related	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A7

Large Cell Medulloblastoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11518	RAB11FIP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB11FIP3	RGD	RGD:1308952
Bos taurus	RAB11FIP3	VGNC	VGNC:33618
Macaca mulatta	RAB11FIP3	VGNC	VGNC:76500
Mus musculus	RAB11FIP3	MGD	MGI:2444431
Felis catus	RAB11FIP3	VGNC	VGNC:64469

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